Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials

The British Journal of Nutrition
Nadia MansoorKjetil Retterstøl

Abstract

The effects of low-carbohydrate (LC) diets on body weight and cardiovascular risk are unclear, and previous studies have found varying results. Our aim was to conduct a meta-analysis of randomised controlled trials (RCT), assessing the effects of LC diets v. low-fat (LF) diets on weight loss and risk factors of CVD. Studies were identified by searching MEDLINE, Embase and Cochrane Trials. Studies had to fulfil the following criteria: a RCT; the LC diet was defined in accordance with the Atkins diet, or carbohydrate intake of <20% of total energy intake; twenty subjects or more per group; the subjects were previously healthy; and the dietary intervention had a duration of 6 months or longer. Results from individual studies were pooled as weighted mean difference (WMD) using a random effect model. In all, eleven RCT with 1369 participants met all the set eligibility criteria. Compared with participants on LF diets, participants on LC diets experienced a greater reduction in body weight (WMD -2·17 kg; 95% CI -3·36, -0·99) and TAG (WMD -0·26 mmol/l; 95% CI -0·37, -0·15), but a greater increase in HDL-cholesterol (WMD 0·14 mmol/l; 95% CI 0·09, 0·19) and LDL-cholesterol (WMD 0·16 mmol/l; 95% CI 0·003, 0·33). This meta-analysis demons...Continue Reading

References

Dec 11, 1992·Journal of Molecular and Cellular Cardiology·D L AtkinsW J Marvin
Aug 1, 1992·The American Journal of Clinical Nutrition·A M Dattilo, P M Kris-Etherton
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 1, 1995·The American Journal of Clinical Nutrition·R M Krauss, D M Dreon
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A Astrup
Sep 21, 2001·Cleveland Clinic Journal of Medicine·G L BlackburnS Morreale
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 18, 2002·Journal of Lipid Research·Kaspar K Berneis, Ronald M Krauss
Nov 28, 2002·JAMA : the Journal of the American Medical Association·Frank B Hu, Walter C Willett
Apr 10, 2003·JAMA : the Journal of the American Medical Association·Dena M BravataDawn M Bravata
May 23, 2003·The New England Journal of Medicine·Gary D FosterSamuel Klein
May 26, 2004·Endocrinology and Metabolism Clinics of North America·Ronald M Krauss, Patty W Siri
Jan 6, 2005·JAMA : the Journal of the American Medical Association·Michael L DansingerErnst J Schaefer
Dec 20, 2005·Journal of Clinical Epidemiology·Toshi A FurukawaNorio Watanabe
May 15, 2009·The American Journal of Clinical Nutrition·Grant D BrinkworthPeter M Clifton
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Aug 21, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S S LimP M Clifton
Jan 15, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Aug 17, 2010·Current Atherosclerosis Reports·Patty W Siri-TarinoRonald M Krauss
Nov 17, 2010·Current Oncology Reports·Karen Basen-Engquist, Maria Chang
Nov 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Christiane L HaaseRuth Frikke-Schmidt
Nov 22, 2011·The Psychiatric Clinics of North America·Angela Makris, Gary D Foster
May 9, 2013·The British Journal of Nutrition·Nassib Bezerra BuenoTerezinha da Rocha Ataide
May 24, 2014·Nature Reviews. Drug Discovery·Bronwyn A KingwellNorman E Miller
Sep 3, 2014·Annals of Internal Medicine·Lydia A BazzanoJiang He

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Citations

Feb 10, 2016·The British Journal of Nutrition·Thomas R WoodGuðmundur F Jóhannsson
Jul 5, 2016·The British Journal of Nutrition·Nadia MansoorKjetil Retterstøl
Oct 26, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·I ZazpeM A Martínez-González
Jan 6, 2017·British Journal of Sports Medicine·Timothy David Noakes, Johann Windt
Mar 16, 2017·Nutrition Research Reviews·Agata Chmurzynska, Monika A Mlodzik
Feb 13, 2018·Nature Reviews. Urology·Jan HammarstenRalph Peeker
Apr 21, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Kevin D Hall, Stephanie T Chung
Sep 9, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C ChuruangsukM Lean
Aug 12, 2018·Diabetes, Obesity & Metabolism·Henny-Kristine Korsmo-HaugenAnne-Marie Aas
Oct 6, 2018·Expert Review of Endocrinology & Metabolism·Eric C WestmanWilliam S Yancy
Nov 2, 2018·The American Journal of Clinical Nutrition·Thomas S KraftMichael Gurven
Nov 27, 2018·International Journal of Epidemiology·Miguel A Martínez-GonzálezUNKNOWN PREDIMED-Plus Study Investigators
Mar 21, 2019·Current Opinion in Oncology·Adeel KaiserChristopher D'Adamo
Apr 23, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Chaitong ChuruangsukEmilie Combet
May 1, 2019·Nutrients·Andrea Mario BollaLorenzo Piemonti
Jul 13, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Caryn ZinnGrant Schofield
Jan 4, 2018·Clinical Chemistry·Christina M AstleyJose C Florez
Dec 12, 2019·The Journal of Nutrition·David S Ludwig
May 30, 2020·Current Atherosclerosis Reports·Carol F KirkpatrickKevin C Maki
Jun 10, 2020·Critical Reviews in Food Science and Nutrition·Francisco Gomez-DelgadoPablo Perez-Martinez
Sep 27, 2019·MMW Fortschritte der Medizin·Marthin KaroffBirna Bjarnason-Wehrens
Mar 8, 2017·American Journal of Lifestyle Medicine·Christopher D Gardner, Michelle E Hauser
Jul 5, 2018·JAMA Internal Medicine·David S Ludwig, Cara B Ebbeling
Nov 16, 2018·BMJ : British Medical Journal·Cara B EbbelingDavid S Ludwig
Apr 12, 2020·International Journal of Environmental Research and Public Health·Tara KellyFrancis Finucane
Sep 15, 2020·Curēus·Jennifer T BatchMonica N Ramirez
Apr 27, 2018·Current Atherosclerosis Reports·Peter M Clifton, Jennifer B Keogh
Dec 7, 2018·Nutrients·Emmanouil KorakasVaia Lambadiari
Oct 20, 2019·Nutrients·Raffaella LongoMaurizio Crestani

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