PMID: 15378139Sep 21, 2004Paper

Effects of low-dose atorvastatin on vascular responses in patients undergoing percutaneous coronary intervention with stenting

Journal of Cardiovascular Pharmacology and Therapeutics
Jang-Ho BaeMichael Schwemmer

Abstract

The primary endpoint of this study was to evaluate the effects of low-dose atorvastatin on carotid intima-media thickness (IMT) and endothelial function, and the secondary endpoint comprised restenosis and target lesion revascularization (TLR) in patients undergoing percutaneous coronary intervention (PCI) with stenting for the treatment of coronary artery disease. Two hundred five consecutive patients (mean age, 60 years) undergoing PCI were prospectively randomized to usual therapy (control group, n = 100) or to 10 mg of atorvastatin daily plus usual therapy (statin group, n = 105). Carotid IMT, endothelial function (flow-mediated dilatation [FMD] of the brachial artery), and coronary angiograms were taken before the study and 6 months after randomization. The 6-month follow-up measurements of the above factors were obtained in 83 patients (83%) of the control group and in 97 patients (92%) of the statin group. No significant differences were noted in the baseline clinical and angiographic findings in either group. FMD was significantly improved during the 6 months in the statin group (4.38% +/- 1.7% vs 4.85% +/- 1.6%, P = .003), but did not change in the control group. Carotid IMT did not show any significant changes at 6 mo...Continue Reading

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Citations

Feb 25, 2005·Current Atherosclerosis Reports·Kerem Ozer, Mehmet Cilingiroglu
Oct 2, 2013·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Darío Echeverri, Jaime Cabrales
May 12, 2012·International Journal of Cardiology·Hisato TakagiTakuya Umemoto
Nov 20, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zhi-Jiang ZhangOscar C Marroquin
Nov 27, 2007·The American Journal of Cardiology·Giacomo LevantesiRoberto Marchioli
Jul 31, 2013·International Journal of Cardiology·Hisato TakagiUNKNOWN All-Literature Investigation of Cardiovascular Evidence (ALICE) Group
Sep 10, 2010·Journal of the American College of Cardiology·David E WinchesterAnthony A Bavry
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Sep 11, 2010·Expert Review of Cardiovascular Therapy·Pradeep K NairOscar C Marroquin
Mar 16, 2007·Critical Care Nursing Quarterly·Lisha KronmannKarl Kronmann

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