PMID: 3433047Oct 1, 1987Paper

Effects of low-dose inhalation of three chlorinated aliphatic organic solvents on deoxyribonucleic acid in gerbil brain

Scandinavian Journal of Work, Environment & Health
J E KarlssonK G Haglid

Abstract

Young adult Mongolian gerbils (Meriones ungiculatus) were continuously exposed by inhalation to 1,1,1-trichloroethane at the Swedish occupational exposure limit (70 ppm), to methylene chloride at three times (210 ppm) the Swedish occupational exposure limit (70 ppm), and to perchloroethylene at three times (60 ppm) the Swedish occupational exposure limit (20 ppm), for three months, followed by a four-month postexposure solvent-free period. The concentrations of deoxyribonucleic acid (DNA) were then determined in different regions of the gerbil central nervous system. It was observed that the DNA concentrations in several brain regions were decreased in the exposed animals. It was found that 1,1,1-trichloroethane induced these alterations in many more brain areas at its Swedish occupational exposure limit than the other solvents studied at threefold their Swedish occupational exposure limits. The results suggest that all the solvents decrease cell density by inhibiting the slow acquisition of DNA or by inducing cell death in some sensitive brain areas and that 1,1,1-trichloroethane should not be regarded as harmless as previously stated.

Citations

Jan 1, 1991·American Journal of Industrial Medicine·P LundbergB Holmberg
Dec 14, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P RidgwayJ-P Leach
May 1, 1994·Archives of Environmental Health·R A HouseM C Wills
May 26, 2011·Toxicology and Applied Pharmacology·Ambuja S BaleGlinda S Cooper
Dec 31, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rebecca Brown DzubowStanley Barone
Jul 1, 1995·Journal of Applied Toxicology : JAT·S Dhillon, R Von Burg

Related Concepts

Inhibisol
Brain
DNA, Double-Stranded
Psammomys
Hydrocarbons, Chlorinated
Solaesthin
Tetrachloroethylene
Trichloroethanes

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