PMID: 20644333Jul 21, 2010Paper

Effects of low-dose simvastatin on the distribution of plasma cholesterol and oxidized low-density lipoprotein in three ultra-centrifugally separated low-density lipoprotein subfractions: 12- month, open-label trial

Journal of Atherosclerosis and Thrombosis
Yasuhiko HommaKanagawa Lipid Research Group

Abstract

The effects of statins on the distribution of oxidized LDL in plasma LDL subfractions have not been well defined. Effects of 12-month treatment with low-dose simvastatin on the distribution of cholesterol and oxidized LDL in 3 ultracentrifugally separated plasma LDL subfractions were compared in patients with hypercholesterolemia. Simvastatin was administered to 30 hypercholesterolemic subjects for 12 months at an initial dose of 5 mg/day, which was increased to 20 mg/day via 10mg/day to decrease plasma LDL-cholesterol (C) lower than 130 mg/dL. Simvastatin dose was fixed after 3 months of treatment. The amounts of cholesterol and oxidized LDL in 3 ultracentrifugally separated plasma LDL subfractions were compared between 0 and 12 months of treatment. The distribution of ox-LDL skewed to denser LDL fractions, compared with cholesterol in plasma LDL subfractions. Plasma cholesterol in low-density LDL, medium-density LDL and high-density LDL decreased significantly by 31%, 30%, and 25%, respectively (p<0.0001) after 12 months of simvastatin treatment. Plasma oxidized LDL was decreased from 70 U/L to 56 U/L in medium-density LDL (p=0.042). Oxidized LDL in low-density LDL and high-density LDL did not change significantly after 12 mo...Continue Reading

References

Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J de GraafA F Stalenhoef
Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K NakajimaE Campos
Jun 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·H CamposR M Krauss
Jan 15, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·T LehtimäkiT Nikkari
Sep 18, 2002·Journal of Lipid Research·Kaspar K Berneis, Ronald M Krauss
Dec 25, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Masunori MatsuzakiUNKNOWN J-LIT Study Group. Japan Lipid Intervention Trial
Dec 31, 2002·Lancet·Patricia D'Antonio
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Nov 24, 2004·Journal of Atherosclerosis and Thrombosis·Yasuhiko Homma
Mar 21, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Joseph L Goldstein, Michael S Brown
Jul 25, 2009·Current Opinion in Lipidology·Yasushi IshigakiHideki Katagiri
Sep 15, 2009·Journal of Atherosclerosis and Thrombosis·Muzeyyen Aslan BahadirOzgur Bahadir

❮ Previous
Next ❯

Citations

Dec 13, 2016·International Urology and Nephrology·Anna Gluba-BrzózkaMagdalena Rysz-Górzyńska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.