Effects of low doses of catecholamine receptor agonists on exploration in mice.

Journal of Neural Transmission
U Strömbom

Abstract

Female mice were given 0.025--0.8 mg/kg of the dopamine and noradrenaline receptor agonists apomorphine and clonidine, respectively, and the effect on explorative behaviour of these drugs was tested in a Y-shaped runway for three minutes. Saline-treated controls displayed a stable exploratory behaviour, declining during the time period measured. The decline probably reflects adaptation to the new environment. Apomorphine depressed the activity, but the configuration of the time curve was the same as in controls. Clonidine also depressed the exploratory activity and further appeared to break the pattern of adaptation, the activity in clonidine-treated mice being low from the beginning. The higher doses of the drugs, alone or in combination, caused a pronounced suppression of the exploration. These mice were observed for ten minutes, under which period their exploration of the runway was not increased, as compared with the first three minutes. The smaller doses used are not known to cause functionally measureable activation of postsynaptic catecholamine receptors. On the other hand these doses are known as cause inhibition of firing in the respective presynaptic neurons and also inhibition of synthesis of the respective transmitt...Continue Reading

References

Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·T H Svensson
Sep 1, 1972·The Journal of Pharmacy and Pharmacology·W KehrC Atack
Jan 1, 1970·International Review of Neurobiology·J M Van Rossum

❮ Previous
Next ❯

Citations

Jan 1, 1984·Psychopharmacology·C A WilmotM T Spoerlein
Aug 15, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·T H Svensson, U Strömbom
Jan 1, 1988·Journal of Neural Transmission·E HårdA S Lindh
Jan 1, 1985·Journal of Neural Transmission·E MogilnickaA Czyrak
Jan 1, 1981·Journal of Neural Transmission·B Persson, T H Svensson
Jan 1, 1982·Journal of Neural Transmission·C Spyraki, H C Fibiger
Jan 1, 1980·Journal of Neural Transmission·U Strömbom, T H Svensson
Sep 10, 1982·European Journal of Pharmacology·A S HornA H Mulder
Nov 19, 1982·European Journal of Pharmacology·B CostallR J Naylor
Jan 13, 1984·European Journal of Pharmacology·T Zetterström, U Ungerstedt
Mar 1, 1988·European Journal of Pharmacology·J Van der WeideA S Horn
Sep 1, 1977·Pharmacology, Biochemistry, and Behavior·D QuartermainB M Gutwein
May 1, 1985·Pharmacology, Biochemistry, and Behavior·G B Freeman, J B Thurmond
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·E VasarL Allikmets
May 1, 1988·Pharmacology, Biochemistry, and Behavior·K IchiharaT Kameyama
Aug 1, 1996·Pharmacology, Biochemistry, and Behavior·T P PiepponenL Ahtee
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·Z AmitS O Ogren
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·M R Lynch
May 1, 1977·Brain Research Bulletin·P Cazala, B Cardo
Jan 1, 1979·Progress in Neuro-psychopharmacology·R M PostW E Bunney
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P Johansson
Jul 5, 2005·Expert Opinion on Investigational Drugs·T A Zesiewicz, R A Hauser
Mar 14, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Philipp SingerBenjamin K Yee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Paolo C Colombani, Samuel Mettler
© 2022 Meta ULC. All rights reserved