PMID: 11924533Apr 2, 2002Paper

Effects of low doses of inhaled nitric oxide combined with oxygen for the evaluation of pulmonary vascular reactivity in patients with pulmonary hypertension

Pediatric Cardiology
E AzekaM Ebaid

Abstract

The purpose of this study was to evaluate the hemodynamic effects of inhaled nitric oxide in oxygen (NO + O2) in patients with pulmonary hypertension. Eighteen patients (median age 31.5 months) with pulmonary hypertension inhaled through a mask 100% O2 and 20 parts per million NO + inspired O2 fraction (FiO2) at 0.4. Hemodynamic measurements were made at baseline and after O2 and NO + O2 administration. The pulmonary vascular resistance index decreased after inhalation of O2 and NO + O2 (p = 0.0018 and p = 0.0003, respectively), the decrease being significantly greater after NO + O2 (p = 0.0311). Concerning the transpulmonary pressure gradient, a reduction occurred in values after O2 and NO + O2 inhalation when compared with baseline values (p = 0.0014 and p = 0.0008). In patients with congenital heart disease, an increase occurred in pulmonary blood flow after O2 (p = 0.0089) and NO + O2 (p = 0.0019) compared with baseline values, and an increase also occurred in the pulmonary/systemic blood flow ratio after NO + O2 (p = 0.0017). The main side effect related to NO + O2 was pulmonary congestion in 3 patients. Low doses of NO combined with O2 demonstrated a selective pulmonary vasodilator response in patients with pulmonary hype...Continue Reading

Citations

Jan 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Weiling XuSerpil C Erzurum
Sep 1, 2008·Clinical and Translational Science·Fares A MasriSerpil C Erzurum
Oct 7, 2006·Free Radical Biology & Medicine·LiChun ZhouZhongMao Guo
Jul 16, 2002·Revista do Hospital das Clínicas·José Otávio Costa AulerDeipara Monteiro Abellan
Feb 12, 2015·Archives of public health = Archives belges de santé publique·Waleed M SweilehAnsam F Sawalha
Apr 23, 2005·The Cochrane Database of Systematic Reviews·N S ParamothayanE H Walters
Oct 6, 2006·Current Opinion in Anaesthesiology·Simon C Hillier
Sep 15, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Weiling XuSerpil C Erzurum
Nov 15, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Edmundo Clarindo OliveiraHelder Machado Pauperio

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