Effects of low doses of Li carbonate injected into mice. Functional changes in kidney seem to be related to the oxidative status

Comptes rendus biologies
R NciriAbdelfattah Elfeki

Abstract

Effects of daily injections of lithium carbonate (20, 40 or 80 mg/kg body weight) during 14 and 28 days were investigated in Wistar mice. Attention was paid (1) to changes in concentrations of lithium, creatinine and urea in serum, (2) to level of oxidative stress by measuring lipids peroxidation level and catalase, superoxide-dismutase and glutathione-peroxidase activities, and (3) to changes in the histological structure of brain. The first intraperitoneal injection was followed by a transitory peak of lithium in the blood, reaching 0.25 mM and 1.1 mM and disappearing 6 and 12 h later for the 20 and 80 mg/kg doses, respectively. From the first to the last day of treatment, lithium concentrations in the blood, measured 12 h after the injections, increased from 0 to 0.11 mM (20 mg/kg dose) or 0.25 mM (80 mg/kg dose). The 80 mg/kg treatment induced a renal insufficiency evidenced by an increase of blood creatinine and urea levels. Lithium treatment was found to trigger an oxidative stress in kidney, but not in brain. In kidney, the lipid peroxidation level (TBARS) and the superoxide dismutase and catalase activities were increased. No change in glutathione peroxidase activity was detected. Histology of the brain cortex revealed ...Continue Reading

References

Nov 1, 1971·Analytical Biochemistry·C Beauchamp, I Fridovich
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Jan 1, 1984·Methods in Enzymology·H Aebi
May 1, 1993·The American Journal of Clinical Nutrition·H Esterbauer
Nov 25, 1998·Thyroid : Official Journal of the American Thyroid Association·J H Lazarus
Jul 9, 1999·Journal of Neuroscience Research·J García-PérezJ Díaz-Nido
Sep 15, 2000·Journal of Neurochemistry·G ChenH K Manji
Mar 1, 2002·Journal of Affective Disorders·M Schou
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tayfun TuranFahrettin Keleştimur
May 23, 2003·Nature·Christopher J PhielPeter S Klein
Nov 5, 2003·Radiology·Maria Teresa FarresAlain Ferdinand Le Blanche
Nov 18, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shai EfratiZhan Averbukh
Apr 2, 2005·Drugs in R&D·Atilla EnginErdal Isik
Sep 1, 2005·Molecular and Cellular Biochemistry·Faruk OktemIrfan Altuntas
Nov 16, 2005·Comptes rendus biologies·Mohamed Salah AllaguiAbdelfettah El Feki
Jun 30, 2006·Journal of Neurochemistry·Barry Halliwell

❮ Previous
Next ❯

Citations

Feb 15, 2013·Biological Trace Element Research·Selmin ToplanMehmet C Akyolcu
Mar 29, 2014·Biological Trace Element Research·Małgorzata KiełczykowskaIrena Musik
Mar 5, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Nciri RiadhAbdelfattah Elfeki
Mar 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R NciriA El Feki
Oct 20, 2019·Bipolar Disorders·Georgina P OssaniDiego J Martino
May 3, 2015·Pharmacological Reports : PR·Irena MusikMałgorzata Kiełczykowska
Mar 25, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Chiara PizzasegolaCaterina Bendotti
Nov 21, 2020·Environmental Science and Pollution Research International·Ikram RouibahHedi Ben Mansour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.