PMID: 8950012Nov 1, 1996Paper

Effects of low doses of physostigmine on avoidance learning and EEG in two strains of mice

Behavioural Brain Research
A LoizzoM Sansone

Abstract

The effects of the cholinomimetic drug, physostigmine (0, 0.01, 0.025, 0.05 and 0.1 mg/kg, i.p.), on shuttle-box avoidance learning and electroencephalographic (EEG) activity were investigated, in two separate studies, in mice belonging to the inbred C57BL/6 (C57) and DBA/2 (DBA) strains. The results of the behavioral investigation showed a consistent, significant enhancement of avoidance performance, on the whole of 5 daily training sessions, in C57 mice treated with the lowest dose (0.01 mg/kg) and in DBA mice treated with the highest doses (0.05 and 0.1 mg/kg) of the drug. Doses higher than 0.01 mg/kg, in C57 mice, and lower than 0.05 mg/kg, in DBA mice, had no significant effect. The avoidance improvements induced by physostigmine cannot be ascribed to general behavioral activation, since the doses that increased avoidance responses did not affect or even depressed spontaneous locomotor activity. The same doses of treatment which increased avoidance responding, also induced, in the same strains, consistent enhancement of 4-7 Hz (theta) EEG band power and decrease of 7-12 Hz (alpha) band power. Results suggest that the effects induced by physostigmine on the EEG and on the shuttle-box performance of mice are related to the s...Continue Reading

References

Jan 1, 1975·Behavioral Biology·L P Lanier, R L Isaacson
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·C Gottesmann
Jan 1, 1992·Behavioral and Neural Biology·H EichenbaumN J Cohen
Jan 1, 1992·Life Sciences·J AntalA Loizzo
Jan 1, 1991·Brain Research Bulletin·A J Heynen, R S Sainsbury
May 1, 1990·Trends in Neurosciences·M Stewart, S E Fox
Feb 11, 1991·Electroencephalography and Clinical Neurophysiology·P RiekkinenJ Partanen
Dec 1, 1991·Trends in Pharmacological Sciences·M Sarter
Nov 1, 1989·Bulletin of Environmental Contamination and Toxicology·P ValenteA Loizzo
Jan 1, 1986·Progress in Neurobiology·B H Bland
Jan 1, 1985·Psychopharmacology·V HaroutunianK L Davis
Feb 3, 1988·Neuroscience Letters·C CastellanoD Biesold
Jan 1, 1987·Physiology & Behavior·R S SainsburyC P Montoya
Oct 13, 1987·European Journal of Pharmacology·H R OlpeC Mondadori
Jul 8, 1970·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·C CastellanoD Bovet
Jan 10, 1969·Science·D BovetA Oliverio
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·D K Ingram, T P Corfman
Aug 1, 1982·Electroencephalography and Clinical Neurophysiology·L W LeungW J Wadman
Oct 1, 1983·Brain Research·G BuzsákiC H Vanderwolf
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Aug 1, 1981·Pharmacology, Biochemistry, and Behavior·M J MarksA C Collins
Jun 1, 1980·Pharmacology, Biochemistry, and Behavior·L P Gonzalez, H L Altshuler
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·M SansoneM Ammassari-Teule
May 1, 1949·Electroencephalography and Clinical Neurophysiology·J TEN CATEL J KOOPMAN

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