Effects of low level lead exposure on associative learning and memory in the rat: Influences of sex and developmental timing of exposure

Toxicology Letters
D W AndersonJay S Schneider

Abstract

Lead (Pb) exposure during development impairs a variety of cognitive, behavioral and neurochemical processes resulting in deficits in learning, memory, attention, impulsivity and executive function. Numerous studies have attempted to model this effect of Pb in rodents, with the majority of studies focusing on hippocampus-associated spatial learning and memory processes. Using a different paradigm, trace fear conditioning, a process requiring coordinated integration of both the medial prefrontal cortex and the hippocampus, we have assessed the effects of Pb exposure on associative learning and memory. The present study examined both female and male long evans rats exposed to three environmentally relevant levels of Pb (150 ppm, 375 ppm and 750 ppm) during different developmental periods: perinatal (PERI; gestation-postnatal day 21), early postnatal (EPN; postnatal days 1-21) and late postnatal (LPN; postnatal days 1-55). Testing began at postnatal day 55 and consisted of a single day of acquisition training, and three post training time points (1, 2 and 10 days) to assess memory consolidation and recall. All animals, regardless of sex, developmental window or level of Pb-exposure, successfully acquired conditioned-unconditioned ...Continue Reading

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Citations

May 2, 2016·Environmental Toxicology and Pharmacology·Chang FengGuangqin Fan
May 16, 2017·Archives of Toxicology·Sebastian HoffmannKatya Tsaioun
Jan 29, 2019·The Journal of Endocrinology·Jirapas SripetchwandeeSiriporn C Chattipakorn
Oct 20, 2018·International Journal of Environmental Research and Public Health·Kinga PolanskaGemma Calamandrei
Apr 16, 2020·International Journal of Molecular Sciences·Anna Maria TartaglioneBarbara Viviani
Sep 25, 2020·International Journal of Molecular Sciences·Ana Carolina Alves OliveiraRafael Rodrigues Lima
Apr 18, 2018·Frontiers in Genetics·Garima SinghJay S Schneider
Dec 8, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ab Latif WaniMohammad Afzal
Jan 31, 2021·Environmental Research·Jaehyun ParkSungho Won
Nov 4, 2021·Journal of Exposure Science & Environmental Epidemiology·Clara G SearsJoseph M Braun

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