PMID: 3475739Jan 1, 1987

Effects of low level radiation upon the hematopoietic stem cell: implications for leukemogenesis

Radiation and Environmental Biophysics
E P CronkiteJ E Bullis

Abstract

These studies have addressed firstly the effect of single small doses of x-rays upon murine hematopoietic stem cells to obtain a better estimate of the Dq. It is small, of the order of 20 rad. Secondly, a dose fractionation schedule that does not kill or perturb the kinetics of hemopoietic cell proliferation was sought in order to investigate the leukemogenic potential of low level radiation upon an unperturbed hemopoietic system. Doses used by others in past radiation leukemogenesis studies clearly perturb hemopoiesis and kill a detectable fraction of stem cells. The studies reported herein show that 1.25 rad every day decrease the CFU-S content of bone marrow by the time 80 rads are accumulated. Higher daily doses as used in published studies on radiation leukemogenesis produce greater effects. Studies on the effect of 0.5, 1.0, 2.0, and 3.0 rad 3 times per week are under way. Two rad 3 times per week produced a modest decrease in CFU-S content of bone marrow after an accumulation of 68 rad. With 3.0 rad 3 times per week an accumulation of 102 rad produced a significant decrease in CFU-S content of bone marrow. Dose fractionation at 0.5 and 1.0 rad 3 times per week has not produced a CFU-S depression after accumulation of 17 ...Continue Reading

References

Mar 30, 1978·Nature·I R Major, R H Mole
Mar 1, 1979·Cell and Tissue Kinetics·F C Monette, J B DeMello
Jul 15, 1977·Journal of Molecular Biology·Y Fujiwara, M Tatsumi
Jan 1, 1976·International Journal of Nursing Studies·M R Ventura
Feb 1, 1976·The Journal of Speech and Hearing Disorders·M R Adams
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J P Murnane, R B Painter
Mar 8, 2008·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·W M Court-Brown, R Doll

Citations

Jan 1, 1989·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·E J AinsworthR J Fry
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S TaniguchiK J Mori
Aug 1, 1995·Radiation and Environmental Biophysics·A JohannissonH Amnéus
Aug 1, 1996·International Journal of Radiation Biology·S A AmundsonR T Okinaka
Mar 24, 2007·Experimental Hematology·K Noy RithidechSanford R Simon
Jan 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R GalliniN G Testa
Dec 1, 1988·International Journal of Radiation Biology·F König, J Kiefer
Nov 12, 2010·International Journal of Radiation Biology·Daila S Gridley, Michael J Pecaut
Jan 10, 2019·Dose-response : a Publication of International Hormesis Society·Witawat JangiamK Noy Rithidech

Related Concepts

Marrow
Cell Survival
Colony-Forming Units Assay
Dose-Response Relationship, Radiation
Colony-Forming Units, Hematopoietic
Leukemia, Radiation-Induced
Mice, Inbred CBA
Mice, Inbred C57BL
Gray Units
Roentgen Rays

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.