Abstract
Low serum triglyceride (TG) has been suggested as a predictor of mortality after cardiovascular disease. However, the relationship between the level of TGs and the outcome after stroke remains to be elucidated. We hypothesized that the influence of TG levels on post-stroke mortality varies according to stroke mechanism: cardioembolic (CE) vs. non-CE causes. We prospectively enrolled a consecutive series of patients with first-ever acute ischemic stroke for 5 years (n=1067), and followed them until the end of 2007 to obtain information on mortality and cause of death. We divided the level of TG into the quartiles, and classified the patients into CE (n=226) and non-CE stroke groups (n=841). The influence of TG level on mortality (all-cause death and vascular death) was examined by univariate and multivariate analyses using Cox regression. All-cause death and vascular death rates showed inverse relationships to the quartiles of TG levels in all patients (p<0.001, both) and also in non-CE stroke group (p<0.001, both), but not in CE stroke group (p=0.17 and p=0.37, respectively). In the Cox-regression analysis, compared with the highest quartile, the adjusted hazard ratio (HR) of the lowest quartile for all-cause death was 2.58 [95...Continue Reading
References
Jan 1, 1993·Stroke; a Journal of Cerebral Circulation·H P AdamsE E Marsh
Nov 20, 1993·BMJ : British Medical Journal·I StensvoldS Graff-Iversen
Apr 29, 1993·The New England Journal of Medicine·M H CriquiC E Davis
Sep 1, 1996·The American Journal of Medicine·S AullK Zeiler
Jan 7, 1998·JAMA : the Journal of the American Medical Association·M W GillmanP A Wolf
Apr 8, 1998·Circulation·J JeppesenF Gyntelberg
Aug 3, 1999·Circulation·M HaimU Goldbourt
Aug 18, 1999·Circulation·S BoquistA Hamsten
Feb 28, 2001·American Journal of Epidemiology·H IsoY Komachi
Aug 28, 2002·Neurology·David W DesmondYaakov Stern
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Seung-Hoon LeeJae-Kyu Roh
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Laura L ListenbergerJean E Schaffer
May 27, 2003·Cerebrovascular Diseases·Christopher J WeirKennedy R Lees
Apr 10, 2004·Stroke; a Journal of Cerebral Circulation·Tomasz DziedzicAndrzej Szczudlik
May 8, 2004·Stroke; a Journal of Cerebral Circulation·Tomasz DziedzicAndrzej Szczudlik
Nov 22, 2005·Lancet·P M RothwellUNKNOWN Oxford Vascular Study
Nov 29, 2005·Lancet·A KeechUNKNOWN FIELD study investigators
Apr 26, 2006·European Neurology·Slaven PikijaNedeljko Sokol
May 30, 2006·Atherosclerosis·Anoop ShankarJie Jin Wang
Dec 22, 2006·The New England Journal of Medicine·Sang Woo Oh
Dec 30, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Benny Hung-Junn Chang, Lawrence Chan
Apr 21, 2007·Stroke; a Journal of Cerebral Circulation·Angela M CarterPeter J Grant
Oct 29, 2008·Atherosclerosis·Julien LabreuchePierre Amarenco
Mar 3, 2009·American Heart Journal·Vera BittnerGeorge Sopko
Mar 17, 2009·Stroke; a Journal of Cerebral Circulation·Beom Joon KimByung-Woo Yoon
Citations
Apr 26, 2012·Rejuvenation Research·Damien BiottiJean-Raymond Teyssier
May 15, 2012·Journal of the Neurological Sciences·Kang-Ho ChoiKi-Hyun Cho
Dec 20, 2011·Atherosclerosis·Wi-Sun RyuByung-Woo Yoon
Mar 13, 2016·Brain Research·Yong ChenChun Wang
Jan 1, 2014·Australasian Journal on Ageing·Chia-Yu HsuYu-Ning Hu
Jul 22, 2014·Atherosclerosis·Ning YangCong Gao
Feb 19, 2015·Journal of Stroke·Jong-Won ChungByung-Woo Yoon
Apr 17, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Slaven PikijaDunja Dukši
Jan 17, 2013·Journal of Clinical Neurology·Dohoung KimByung-Woo Yoon
Jul 8, 2017·Neurological Research·Kyusik KangByung Kun Kim
Dec 5, 2017·Brain and Behavior·Sha-Sha LiHui-Sheng Chen
Jan 24, 2019·Lipids in Health and Disease·Tian-Li XiaDe-Jia Huang
May 1, 2020·The Journal of Clinical Endocrinology and Metabolism·Wendy A DavisTimothy M E Davis
Jan 1, 2013·Neuroscience Journal·Minal JainLatha Ganti Stead
Nov 20, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Q-W DengF-L Yan
Jun 2, 2017·Journal of Thrombosis and Thrombolysis·Kyusik KangByung Kun Kim
Dec 15, 2019·Lipids in Health and Disease·Bumjo OhSohyun Chun
Sep 14, 2018·Frontiers in Neurology·Kai-Hung ChengUNKNOWN SRICHS Group
Dec 15, 2020·American Journal of Obstetrics and Gynecology·Maryam KazemiMarla E Lujan
Jan 19, 2021·Journal of Epidemiology·Aya HirataHirotsugu Ueshima
Aug 8, 2020·American Journal of Human Genetics·Allison MeisnerNilanjan Chatterjee
Sep 10, 2021·BMC Cardiovascular Disorders·Fei LiJianzeng Dong
Nov 4, 2021·World Neurosurgery·Sauson SoldozyM Yashar S Kalani