PMID: 7541466Apr 15, 1995Paper

Effects of lowered cytoplasmic calcium concentration and light on the responses of salamander rod photoreceptors

The Journal of Physiology
Hugh R Matthews

Abstract

1. In order to study the interactions between cytoplasmic calcium concentration ([Ca2+]i) and light in modulating the responses of rod photoreceptors, [Ca2+]i was held at different levels by manipulating Ca2+ fluxes across the outer segment membrane. 2. If [Ca2+]i was reduced by the removal of external Ca2+ in the continued presence of Na+, and then held near this reduced level by exposure to 0 Ca(2+)-0 Na+ solution, the onset of the recovery phase of the response to a bright flash delivered just before the return to Ringer solution was accelerated, much as is the case during light adaptation, provided that precautions were taken to minimize Na+ influx. 3. If the rod was first allowed to adapt to steady light, [Ca2+]i held near the appropriate light-adapted level by superfusion with 0 Ca(2+)-0 Mg(2+)-0 Na+ solution and the light extinguished, the onset of the recovery phase of the bright flash response varied with the original background intensity in the same way as in the continued presence of steady light. These results indicate that reduction of [Ca2+]i is sufficient to induce this manifestation of light adaptation in darkness. 4. When [Ca2+]i was held at a reduced level in darkness, not only was the sensitivity to dim flash...Continue Reading

Citations

Sep 2, 2003·The Journal of Physiology·Hugh R Matthews, Gordon L Fain
Aug 24, 1999·The Journal of Physiology·J Reisert, H R Matthews
Apr 18, 2001·The Journal of Physiology·H R Matthews, G L Fain
Jul 4, 2001·The Journal of Physiology·J Reisert, H R Matthews
Nov 25, 2006·The Journal of Physiology·Yiu Tak LeungHugh R Matthews
Nov 10, 1998·The Journal of General Physiology·J Reisert, H R Matthews
Mar 17, 2010·The Journal of General Physiology·Hugh R Matthews, Alapakkam P Sampath
Jul 18, 2012·The Journal of General Physiology·Jingjing Zang, Hugh R Matthews
Feb 14, 1998·The Journal of General Physiology·A P SampathG L Fain
Feb 14, 1998·The Journal of General Physiology·S NikonovE N Pugh
Jan 16, 2004·IEEE Transactions on Bio-medical Engineering·Gabriel A Silva, David R Pepperberg
Sep 30, 2015·The Journal of General Physiology·Frans VinbergAri Koskelainen
Oct 5, 2001·The Journal of General Physiology·H R MatthewsR K Crouch
Oct 9, 2002·Neuron·Marie E BurnsDenis A Baylor
Aug 16, 2006·Neuron·Claudia M KrispelMarie E Burns
May 16, 2006·Biophysical Journal·Andreas Knopp, Hartmann Rüppel
Dec 8, 2004·Visual Neuroscience·Marianne C CilluffoGordon L Fain
Oct 11, 2005·Visual Neuroscience·R D HamerJ L P Jarvinen
Aug 25, 2001·Annual Review of Neuroscience·M E Burns, D A Baylor
Nov 12, 2003·The Journal of General Physiology·Claudia M KrispelMarie E Burns
Mar 20, 2018·The Journal of Biological Chemistry·Frans VinbergVladimir J Kefalov
Oct 29, 2008·The Journal of General Physiology·Luba A AstakhovaVictor I Govardovskii
Jan 12, 2001·Physiological Reviews·G L FainY Koutalos
May 1, 2010·Physiology·Marie E Burns, Edward N Pugh
Nov 9, 2000·Progress in Retinal and Eye Research·T Ebrey, Y Koutalos
Nov 1, 1996·Trends in Neurosciences·G L FainM C Cornwall
Feb 1, 1996·Trends in Neurosciences·Y Koutalos, K W Yau

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