Apr 2, 1998

Effects of loxiglumide on pancreatic exocrine secretion stimulated by meal in conscious dogs

Arzneimittel-Forschung
K NinomiyaM Fujii

Abstract

The effects of loxiglumide (CAS 107097-80-3, CR 1505), a novel cholecystokinin-A(CCK-A) receptor antagonist, on pancreatic exocrine secretion stimulated by meal were examined in conscious dogs with chronic pancreatic fistula. Pancreatic exocrine secretion was stimulated by intraduodenal infusion of a liquid test meal and postprandial plasma CCK levels were apparently elevated. Loxiglumide inhibited the meal-stimulated outputs of pancreatic protein, amylase and bicarbonate at an intravenous dose of 10 mg/kg/h (p < 0.05). However, loxiglumide did not show apparent inhibition of pancreatic juice volume and trypsin output. These results show that the selective CCK-A antagonist loxiglumide may inhibit the increase of pancreatic exocrine secretion based on selective blockade of receptor binding of CCK endogenously induced by meal in dogs.

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Mentioned in this Paper

Cholecystokinin
CR 1505
Pancreatic Exocrine Secretion
Loxiglumide
CCKAR
Hormone Antagonists
Antagonist Muscle Action
Cholecystokinin Measurement
Carbonic Acid Ions
Food Interactions

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