Effects of LSD on grooming behavior in serotonin transporter heterozygous (Sert⁺/⁻) mice

Behavioural Brain Research
Evan J KyzarA V Kalueff

Abstract

Serotonin (5-HT) plays a crucial role in the brain, modulating mood, cognition and reward. The serotonin transporter (SERT) is responsible for the reuptake of 5-HT from the synaptic cleft and regulates serotonin signaling in the brain. In humans, SERT genetic variance is linked to the pathogenesis of various psychiatric disorders, including anxiety, autism spectrum disorders (ASD) and obsessive-compulsive disorder (OCD). Rodent self-grooming is a complex, evolutionarily conserved patterned behavior relevant to stress, ASD and OCD. Genetic ablation of mouse Sert causes various behavioral deficits, including increased anxiety and grooming behavior. The hallucinogenic drug lysergic acid diethylamide (LSD) is a potent serotonergic agonist known to modulate human and animal behavior. Here, we examined heterozygous Sert(+/-) mouse behavior following acute administration of LSD (0.32 mg/kg). Overall, Sert(+/-) mice displayed a longer duration of self-grooming behavior regardless of LSD treatment. In contrast, LSD increased serotonin-sensitive behaviors, such as head twitching, tremors and backwards gait behaviors in both Sert(+/+) and Sert(+/-) mice. There were no significant interactions between LSD treatment and Sert gene dosage in ...Continue Reading

References

Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·S M Meehan, M D Schechter
Aug 7, 2004·Brain Research. Brain Research Protocols·Allan V Kalueff, Pentti Tuohimaa
Jul 18, 2006·Current Pharmaceutical Design·J A J SchmittW J Riedel
Aug 30, 2007·Nature Neuroscience·Turhan Canli, Klaus-Peter Lesch
Oct 16, 2007·Pharmacology, Biochemistry, and Behavior·C M KrallJ C Winter
Jan 23, 2008·Nature Reviews. Neuroscience·Dennis L Murphy, Klaus-Peter Lesch
Dec 2, 2008·CNS Neuroscience & Therapeutics·Torsten PassieAnnelie Hintzen
Jul 7, 2009·Brain Research·Jennifer Joeyen-WaldorfEtienne Sibille
Aug 25, 2009·Neuroscience and Biobehavioral Reviews·A V KalueffJ R Homberg
Feb 17, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomás PálenícekJirí Horácek
Mar 30, 2010·Behavioural Brain Research·Lars LewejohannNorbert Sachser
Jun 19, 2010·Nature Reviews. Neuroscience·Jill L SilvermanJacqueline N Crawley
Aug 19, 2010·Nature Reviews. Neuroscience·Franz X Vollenweider, Michael Kometer
Nov 5, 2010·Biological Psychiatry·Judith R Homberg, Klaus-Peter Lesch
Jan 25, 2011·Neuropharmacology·Adam L Halberstadt, Mark A Geyer
Jun 13, 2013·Nature Reviews. Neuroscience·David J NuttDavid E Nichols
Sep 6, 2013·Behavioural Brain Research·Robert HaberzettlMeredith A Fox
Feb 26, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kathryn SandbergUNKNOWN Georgetown Consensus Conference Work Group

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Citations

Nov 26, 2016·International Journal of Molecular Sciences·Danilo De GregorioGabriella Gobbi
Sep 5, 2021·Scientific Reports·Ramona M RodriguizWilliam C Wetsel

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