PMID: 6980871Jun 1, 1982Paper

Effects of lung inflation on alveolar epithelial solute and water transport properties

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
K J Kim, E D Crandall

Abstract

Paired hollow bullfrog lungs (Rana catesbeiana) were used to study the effects of lung inflation on alveolar epithelial transport of water and hydrophilic solutes. Frogs were double pithed and the lungs were removed after bronchial placement of a Lucite plug. Three openings in the plug accommodated the insertion of two agar-Ringer bridges (for electrical potential measurement and passage of direct current) and the injection and removal of alveolar bathing fluid. Ringer solution containing a tracer quantity of radioactive solute was instilled into the lung sacs (5 ml or 50 ml) and the lungs were suspended in baths of Ringer solution containng appropriate cold solutes (5 mM). Permeability properties of each solute (and water) were determined from the rate of radiotracer concentration change in the bath. The spontaneous potential difference, tissue resistance, and solute permeability properties determined in these experiments showed no significant differences between the 5- and 50-ml lungs. Assuming homogeneous, cylindrical water-filled pores to be present in the tissue, the equivalent pore radii estimated from the rates of solute and water fluxes were 1.1 (for 5-ml lungs) and 0.9 nm (for 50-ml lungs). After overinflation of the l...Continue Reading

Citations

Jan 1, 1985·Pediatric Pulmonology·A A HutchisonG M Loughlin
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·J D RicardG Saumon
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Kenneth J Cavanaugh, Susan S Margulies
Jun 4, 2010·American Journal of Physiology. Cell Physiology·Brian C DiPaoloSusan S Margulies
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·D J TschumperlinA S Margulies
Jun 16, 1999·Journal of Applied Physiology·D J Tschumperlin, S S Margulies
Jan 31, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brian C DiPaolo, Susan S Margulies
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Jan 1, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·N DavidovichS S Margulies
Nov 12, 2005·American Journal of Physiology. Cell Physiology·Kenneth J CavanaughSusan S Margulies
Jul 2, 2010·PloS One·Taylor S CohenSusan S Margulies
Dec 9, 1998·The American Journal of Physiology·D J Tschumperlin, S S Margulies

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