PMID: 26320496Sep 1, 2015Paper

Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats

Asian Pacific Journal of Cancer Prevention : APJCP
Elif OguzNurten Aksoy

Abstract

Methotrexate (Mtx), used for its anticancer and immunsuppresive properties, is known to be a nephrotoxic agent. We aimed to investigate the effects of lycopene (Lyc) alone or combined with melatonin (Mel) on Mtx- induced nephrotoxicity since both of these agents have antioxidant and anti-inflammatory effects. Nephrotoxicity was induced by intraperitoneal administration of methotrexate at a dose of 20 mg/kg. Treatment both with Lyc alone and Lyc combined with Mel provided significant reduction in tumor necrosis factor-alpha, interleukin 1-beta and ceruloplasmin levels in Mtx administered rats. Hovewer, Lyc combined with Mel provided a significant reduction also in NO levels. Hstopathological examination showed that there was an obvious improvement in the degenerative changes compared to Mtx administrated group with the Lyc combined Mel group giving best protection. In conclusion Lyc alone and combined with Mel provided significant improvement against renal damage caused by Mtx, preseumably via antioxidant and anti-inflammatory activities.

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Citations

Aug 18, 2018·Expert Opinion on Drug Metabolism & Toxicology·Hamed Haghi-AminjanMohammad Abdollahi
Oct 20, 2018·BioFactors·Narges HedayatiGholamreza Karimi
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May 5, 2018·Oxidative Medicine and Cellular Longevity·Nenad StojiljkovicGordana Kocic
Jul 3, 2021·International Journal of Molecular Sciences·Yu-Chieh ChenLi-Tung Huang

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