PMID: 7513065May 1, 1994Paper

Effects of lymphocyte subpopulations on the clonal assay of HPRT mutants: occupational exposure to cytostatic drugs

Mutation Research
H DubeauK Messing

Abstract

The mutagenic effect of occupational exposure to antineoplastic agents was studied in chemotherapy nurses and pharmacists using the T-lymphocyte clonal assay. A significant increase in mutant frequency was observed compared to controls. However, in the present study, cloning efficiency without selection (CEU) was significantly reduced in exposed personnel raising the possibility of an overestimation of the calculated MF. Changes in lymphocyte populations and clonal potential of T-cells were also observed following exposure. CEU was related to % CD4 cells but CE with selection (CETG) was not. Differences in clonal ability of T-cells under selective and unselective conditions coupled with differential lethal effect of antineoplastic agents on lymphocyte subsets may result in inaccurate estimation of MF.

References

Jun 9, 1979·Lancet·K FalckL R Holsti
Jan 1, 1989·Environmental and Molecular Mutagenesis·J P O'NeillR J Albertini
Jun 13, 1988·Journal of Immunological Methods·N OudrhiriF Reyes
Aug 1, 1987·Mutation Research·T FeatherstoneH J Evans
Dec 1, 1985·Mutation Research·A A MorleyR S Seshadri
Oct 1, 1982·European Journal of Cancer & Clinical Oncology·B PetriniH Blomgren
Nov 1, 1984·International Journal of Radiation Oncology, Biology, Physics·G JobW Hunstein
Sep 1, 1984·Mechanisms of Ageing and Development·K J TrainorA A Morley
Dec 1, 1984·Australian and New Zealand Journal of Medicine·A ChrysostomouA A Morley
Sep 1, 1983·Archives of Toxicology·B Kolmodin-HedmanK Falck
Apr 1, 1984·Scandinavian Journal of Immunology·A ChrysostomouA A Morley
Mar 10, 1983·Nature·A A MorleyR G Ryall
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R J AlbertiniW R Borcherding
Dec 1, 1980·Scandinavian Journal of Work, Environment & Health·H NorppaE Nordman

❮ Previous
Next ❯

Citations

Jan 1, 1996·Environmental and Molecular Mutagenesis·V SaddiB W Glickman
Jul 5, 1996·Mutation Research·M Khaidakov, B W Glickman
May 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Roberta TurciClaudio Minoia
Jun 1, 1996·Pharmacology & Toxicology·L S OlsenK Wassermann
Dec 4, 2008·International Journal of Hygiene and Environmental Health·Nevenka KopjarDavor Zeljezić

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.