PMID: 1208627Sep 1, 1975Paper

Effects of lysergic acid diethylamide (LSD) on temporal recovery (pre-pulse inhibition) of the acoustic startle response in the rat

Pharmacology, Biochemistry, and Behavior
M Davis, M H Sheard

Abstract

In a series of 6 experiments 40 mug/kg d-lysergic acid diethylamide (LSD) augmented acoustic startle amplitude in rats when long intertone intervals (4, 8, 16, or 32 sec) were used but not when short interstimulus intervals were used (0.02, 0.1, 0.5, 1, or 2 sec). In contrast, 8 mg/kg d-amphetamine augmented startle when either long or short interstimulus intervals were used. The results suggest that LSD augments startle by accelerating the decay of pre-pulse inhibition (temporal recovery process) which may be one mechanism by which LSD can alter sensory processing.

References

Dec 1, 1974·Journal of Comparative and Physiological Psychology·R N Leaton
Sep 1, 1974·Pharmacology, Biochemistry, and Behavior·M Davis, M H Sheard
Jun 1, 1973·Journal of Comparative and Physiological Psychology·C J Wilson, P M Groves
Mar 1, 1974·Physiology & Behavior·P M GrovesS W Miller
Jan 1, 1969·Annual Review of Medicine·D X Freedman
Jun 1, 1971·Journal of Comparative and Physiological Psychology·J R Ison, G R Hammond
Feb 1, 1970·The Journal of the Acoustical Society of America·H S Hoffman, B L Wible
Aug 1, 1970·Journal of Comparative and Physiological Psychology·M Davis
Feb 1, 1968·The Journal of the Acoustical Society of America·H S Hoffman, J L Searle
Jan 1, 1969·Journal of Comparative and Physiological Psychology·W W Grings, A M Schell
Oct 1, 1965·Journal of Psychosomatic Research·C ShagassS R Krishnamoorti
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