Effects of lytic polysaccharide monooxygenase oxidation on cellulose structure and binding of oxidized cellulose oligomers to cellulases

The Journal of Physical Chemistry. B
Josh V VermaasChristina M Payne

Abstract

In nature, polysaccharide glycosidic bonds are cleaved by hydrolytic enzymes for a vast array of biological functions. Recently, a new class of enzymes that utilize an oxidative mechanism to cleave glycosidic linkages was discovered; these enzymes are called lytic polysaccharide monooxygenases (LPMO). These oxidative enzymes are synergistic with cocktails of hydrolytic enzymes and are thought to act primarily on crystalline regions, in turn providing new sites of productive attachment and detachment for processive hydrolytic enzymes. In the case of cellulose, the homopolymer of β-1,4-d-glucose, enzymatic oxidation occurs at either the reducing end or the nonreducing end of glucose, depending on enzymatic specificity, and results in the generation of oxidized chemical substituents at polymer chain ends. LPMO oxidation of cellulose is thought to produce either a lactone at the reducing end of glucose that can spontaneously or enzymatically convert to aldonic acid or 4-keto-aldose at the nonreducing end that may further oxidize to a geminal diol. Here, we use molecular simulation to examine the effect of oxidation on the structure of crystalline cellulose. The simulations highlight variations in behaviors depending on the chemical...Continue Reading

References

Feb 1, 1996·Journal of Molecular Graphics·W HumphreyK Schulten
Oct 1, 1996·Biophysical Journal·J K Myers, C N Pace
Jun 10, 1998·Journal of Molecular Biology·F B Sheinerman, C L Brooks
Mar 1, 1985·Physical Review A: General Physics·W G Hoover
Aug 1, 2002·Journal of the American Chemical Society·Yoshiharu NishiyamaHenri Chanzy
Aug 22, 2002·Journal of the American Chemical Society·Anu KoivulaT Alwyn Jones
Nov 20, 2003·Journal of the American Chemical Society·Yoshiharu NishiyamaPaul Langan
Oct 14, 2005·Journal of Computational Chemistry·James C PhillipsKlaus Schulten
Nov 22, 2005·Carbohydrate Research·James F MatthewsJohn W Brady
Mar 21, 2007·Journal of Chemical Information and Modeling·Anthony D Hill, Peter J Reilly
May 13, 2008·Journal of Computational Chemistry·Olgun GuvenchAlexander D Mackerell
Apr 16, 2009·The Journal of Physical Chemistry. B·Ruhong ZhouAjay K Royyuru
May 16, 2009·Journal of Computational Chemistry·B R BrooksM Karplus
Feb 18, 2010·Journal of Chemical Theory and Computation·Olgun GuvenchAlexander D Mackerell
Aug 13, 2010·The Journal of Physical Chemistry. B·Andrew PohorilleChristophe Chipot
Oct 12, 2010·Science·Gustav Vaaje-KolstadVincent G H Eijsink
Nov 6, 2010·The Journal of Biological Chemistry·Mihhail Kurasin, Priit Väljamäe
Dec 21, 2010·Current Opinion in Biotechnology·Gregg T BeckhamMichael F Crowley
Mar 24, 2011·The Journal of Physical Chemistry. B·Gregg T BeckhamMichael F Crowley
Mar 24, 2011·The Journal of Physical Chemistry. B·Sami PaavilainenIlpo Vattulainen
Apr 2, 2011·The Journal of Physical Chemistry. B·Gregg T Beckham, Michael F Crowley
Jul 13, 2011·Protein Science : a Publication of the Protein Society·Zarah ForsbergVincent G H Eijsink
Aug 9, 2011·Applied and Environmental Microbiology·James A LangstonMatt D Sweeney
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·R Jason QuinlanPaul H Walton
Sep 3, 2011·Science·Kiyohiko IgarashiMasahiro Samejima
Sep 29, 2011·Journal of Computational Chemistry·Thomas SteinbrecherDavid A Case
Nov 30, 2011·Journal of Chemical Theory and Computation·Olgun GuvenchAlexander D Mackerell
Dec 23, 2011·Journal of the American Chemical Society·William T BeesonMichael A Marletta
Jan 24, 2012·Nature Reviews. Microbiology·Felix Mba MedieBernard Henrissat
Jan 1, 2011·Annual Review of Chemical and Biomolecular Engineering·Shishir P S ChundawatBruce E Dale
Jun 1, 2012·The Journal of Biological Chemistry·Lintao BuGregg T Beckham
Jun 27, 2012·The Journal of Biological Chemistry·Jürgen JalakPriit Väljamäe
Jul 4, 2012·Biotechnology for Biofuels·Svein Jarle HornVincent Gh Eijsink
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Finn L AachmannGustav Vaaje-Kolstad
Feb 16, 2013·Enzyme and Microbial Technology·Leigh MurphyPeter Westh

❮ Previous
Next ❯

Citations

Jan 13, 2016·Applied Microbiology and Biotechnology·Lene LangePeter Kamp Busk
Oct 20, 2015·Applied Microbiology and Biotechnology·Thamy Lívia Ribeiro CorrêaGonçalo Amarante Guimarães Pereira
Oct 17, 2015·Trends in Biotechnology·Glyn R HemsworthPaul H Walton
Dec 10, 2017·The Journal of Biological Chemistry·Zarah ForsbergVincent G H Eijsink
Nov 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Josh V VermaasBrandon C Knott
Aug 30, 2017·Applied Microbiology and Biotechnology·Yongtao Zhu, Mark J McBride
Aug 26, 2020·Journal of Industrial Microbiology & Biotechnology·Heidi ØstbyAnikó Várnai
Jan 10, 2018·Microbial Biotechnology·Mariane Paludetti ZubietaAndré Ricardo de Lima Damasio
Jul 17, 2015·The Journal of Biological Chemistry·Anna S BorisovaVincent G H Eijsink
Dec 5, 2018·Nature Communications·Katrin BesserSimon J McQueen-Mason
Oct 14, 2017·Nature Communications·Manuel EibingerBernd Nidetzky
Jan 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Bastien BissaroÅsmund K Røhr
Sep 28, 2018·Microbiology and Molecular Biology Reviews : MMBR·Bastien BissaroVincent G H Eijsink
Oct 25, 2020·Trends in Plant Science·Guru JagadeeswaranAndrew J Mort
Mar 7, 2021·The Journal of Biological Chemistry·Malene Billeskov KellerPeter Westh
Mar 30, 2021·World Journal of Microbiology & Biotechnology·Patrícia F ÁvilaRosana Goldbeck
Apr 30, 2017·International Journal of Biological Macromolecules·Antonielle Vieira Monclaro, Edivaldo Ximenes Ferreira Filho
Mar 3, 2018·Biochemistry·Bastien BissaroÅsmund K Røhr

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.