Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells

Journal of Dermatological Science
AnggakusumaJae-Kwan Hwang

Abstract

UVB irradiation (290-320 nm) is the most damaging component of the UV spectrum and causes both direct and indirect damage to the basal cell layer of the epidermis; this results in the activation of a number of signaling pathways involved in pathophysiological processes in the skin, such as photoaging and inflammation. In photoaging UVB irradiation promotes degradation of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) and, in inflammation, UVB irradiation promotes the expression of inducible cyclooxygenase (COX-2), leading to overproduction of inflammatory mediators. We first investigated the protective effects of macelignan from Myristica fragrans Houtt. on immortalized human keratinocytes (HaCaT) against UVB damage. We then explored the inhibitory effects of macelignan on UVB-induced MMP-9 and COX-2 and investigated the molecular mechanism underlying those effects. HaCaT cells were treated with macelignan for the indicated times followed by irradiation with UVB. Secretion of MMP-9 was measured by gelatin zymography. Expression of COX-2, mitogen-activated protein kinases (MAPKs), phosphatidylinositol 3-kinase/Akt (PI3K/Akt), c-Fos, c-Jun, and CREB were assayed by western analysis. Macelignan at a concentrati...Continue Reading

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Citations

Feb 26, 2013·Archives of Pharmacal Research·Saswati PaulJung-Soo Han
May 3, 2011·Biological & Pharmaceutical Bulletin·Eun-Jung ChoiJae-Kwan Hwang
Jan 17, 2012·International Journal of Molecular Medicine·Fuquan LinAie Xu
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Jul 21, 2020·Oxidative Medicine and Cellular Longevity·Hee-Jeong ChoiSang-Han Lee
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Apr 24, 2021·International Immunopharmacology·Yuanjie LiHanqing Wang
Feb 2, 2019·Aging and Disease·Wei ZhuangYumin Luo

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