Effects of magnesium on matrix metalloproteinase-2 production in cultured rat cardiac fibroblasts

Basic Research in Cardiology
Hong YueTakanori Ueda

Abstract

The precise correlation between magnesium and cardiac disease remains to be established. Matrix metalloproteinases (MMPs) are important in cardiac disease such as heart failure. Cardiac fibroblasts are the most abundant cell type in the heart and play an important role in the regulation of collagen degradation by MMPs. To assess the association between magnesium and MMPs, we examined the effects of different extracellular magnesium concentrations (0-3.0 mmol/L) on MMP-2 production in cultured rat cardiac fibroblasts. Using gelatin zymography and western blotting, we found that magnesium reduced MMP-2 production dose-dependently, and this effect was inhibited by the tyrosine kinase inhibitors, genistein or herbimycin A. The results of this study indicated that the beneficial effect of magnesium supplementation on the cardiac disease may be due, at least in part, to the inhibitory effect of magnesium on production of MMPs in cardiac fibroblasts, which appears to be mediated by a protein tyrosine phosphorylation related signal transduction pathway.

Citations

Apr 12, 2005·Basic Research in Cardiology·A KamkinH Scholz
Aug 10, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Britta HusseMichael Gekle
Dec 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manuela Martins-GreenMin Yao
Feb 14, 2020·BMC Nephrology·Rami AzemGeorges N Na Khoul
Jun 13, 2018·International Journal of Molecular Sciences·Krasimir Kostov, Lyudmila Halacheva
Mar 1, 2019·Nutrients·Nicoline H J Leenders, Marc G Vervloet
Jul 28, 2020·International Journal of Molecular Sciences·Philipp GlobigBérengère J C Luthringer-Feyerabend
Jan 10, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicoline H J LeendersMarc G Vervloet

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