PMID: 702659Oct 1, 1978Paper

Effects of magnesium oxide on the crystallization of calcium salts in urine in patients with recurrent nephrolithiasis

The Journal of Urology
C D FetnerC Y Pak

Abstract

The effect of oral administration of magnesium oxide on the crystallization in urine of calcium oxalate and brushite was determined in 4 cases of recurrent calcium nephrolithiasis. Each patient was evaluated while on a constant metabolic diet before, during and after therapy with magnesium (1,000 mg. magnesium as magnesium oxide per day). During magnesium therapy urinary hydrogen ion concentration increased by approximately 0.5 unit in all 4 patients and urinary calcium increased about 50 mg. per day in 2. Urinary oxalate decreased significantly in 1 patient and urinary phosphorus was reduced in 2. The urinary activity product ratio of brushite (state of saturation) increased, owing largely to the rise in urinary hydrogen ion concentration but that of calcium oxalate was not changed significantly by magnesium treatment. Although urinary magnesium increased significantly there was no significant change in the urinary formation product ratio (limit of metastability) or the rate of crystal growth of brushite or calcium oxalate. Thus, no beneficial effect of magnesium therapy could be demonstrated in this short-term study.

References

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Citations

May 1, 1991·The Journal of Urology·C J SuR L Hackett
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·G Johansson
Feb 15, 2002·American Journal of Veterinary Research·Chalermpol LekcharoensukLaurie L Swanson
Mar 26, 2002·American Journal of Veterinary Research·Chalermpol LekcharoensukLaurie L Swanson
Nov 19, 2009·Urological Research·B S BibilashY M Fazil Marickar
Nov 8, 2001·Journal of the American Veterinary Medical Association·C LekcharoensukL L Swanson
Apr 7, 2005·Urologia Internationalis·Diana J ZimmermannAlbrecht Hesse
May 8, 2001·Journal of Endourology·B F SchwartzM L Stoller
May 1, 1995·The British Journal of Nutrition·R Siener, A Hesse
Feb 1, 1990·Journal of the American College of Nutrition·J S LindbergC Y Pak
May 2, 2008·Journal of the American Society of Nephrology : JASN·Olivier BonnyOrson W Moe
Sep 1, 1981·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W B Gill
Jan 1, 1984·Molecular Aspects of Medicine·R NathS Farooqui
Oct 1, 1982·Urology·M I ResnickW H Boyce
Jun 15, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sonja Lewandowski, Allen L Rodgers
May 24, 2006·Pediatric Clinics of North America·Julie A Nicoletta, Marc B Lande

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