Effects of malathion metabolites on degranulation of and mediator release by human and rat basophilic cells

Journal of Toxicology and Environmental Health
S Xiong, K E Rodgers

Abstract

In the present study, the effects of malathion and malathion derivatives on histamine and beta-hexosaminidase release by RBL-1 cells, rat peritoneal mast cells (RPMC), and human peripheral blood basophils (HPBB) and cutaneous mast calls were examined. One hour of incubation of RBL-1 cells with all organophosphate compounds tested, except for malathion and malathion monoacid, led to an increase in histamine release. beta-Hexosaminidase, an enzyme released by basophilic cells and a biochemical marker of degranulation, was not released from RBL-1 cells after 1 h of exposure to organophosphate compounds. Within 4 h, all compounds tested increased the release of histamine and beta-hexosaminidase. Longer exposures led to a decrease in the concentration of the compound that was required to cause mediator release. Exposure of RPMC to organophosphate compounds, with the exception of malathion monoacid and malathion (30 min) or malathion monoacid (1 h), led to the release of histamine, but not beta-hexosaminidase. Incubation of HPBB with malaoxon (51.4 +/- 2.8% total histamine released), malathion diacid (25.7 +/- 2.9%), beta-malathion monoacid (31.4 +/- 2.8%), and isomalathion (57.1 +/- 17.1%) for 1 h led to the release of histamine. On...Continue Reading

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Citations

Mar 13, 2008·Environmental Health Perspectives·Becky J ProskocilAllison D Fryer
Jun 29, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Frances C ShaffoPamela J Lein
Nov 24, 1999·Journal of Applied Physiology·A N FreedR Suzuki

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