Effects of male hypogonadism on regional adipose tissue fatty acid storage and lipogenic proteins.

PloS One
Sylvia Santosa, M D Jensen

Abstract

Testosterone has long been known to affect body fat distribution, although the underlying mechanisms remain elusive. We investigated the effects of chronic hypogonadism in men on adipose tissue fatty acid (FA) storage and FA storage factors. Twelve men with chronic hypogonadism and 13 control men matched for age and body composition: 1) underwent measures of body composition with dual energy x-ray absorptiometry and an abdominal CT scan; 2) consumed an experimental meal containing [(3)H]triolein to determine the fate of meal FA (biopsy-measured adipose storage vs. oxidation); 3) received infusions of [U-(13)C]palmitate and [1-(14)C]palmitate to measure rates of direct free (F)FA storage (adipose biopsies). Adipose tissue lipoprotein lipase, acyl-CoA synthetase (ACS), and diacylglycerol acetyl-transferase (DGAT) activities, as well as, CD36 content were measured to understand the mechanism by which alterations in fat storage occur in response to testosterone deficiency. Results of the study showed that hypogonadal men stored a greater proportion of both dietary FA and FFA in lower body subcutaneous fat than did eugonadal men (both p<0.05). Femoral adipose tissue ACS activity was significantly greater in hypogonadal than eugonada...Continue Reading

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Citations

Feb 5, 2013·The Journal of Endocrinology·Daniel M Kelly, T Hugh Jones
May 20, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D M Kelly, T H Jones
May 5, 2016·Adipocyte·Maria Morgan-BathkeMichael D Jensen
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Jan 16, 2018·International Journal of Endocrinology·Jing ChengYingli Lu
Feb 24, 2015·Metabolic Brain Disease·Hiranya PintanaSiriporn Chattipakorn
Jun 24, 2017·The Journal of Clinical Endocrinology and Metabolism·Sylvia SantosaMichael D Jensen
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Dec 3, 2014·Hormone Molecular Biology and Clinical Investigation·Sylvia Santosa, Michael D Jensen
Mar 5, 2015·American Journal of Physiology. Endocrinology and Metabolism·Maria Morgan-BathkeMichael D Jensen
Oct 8, 2020·Hepatology Communications·Somaya AlbhaisiArun J Sanyal
Sep 7, 2019·Journal of Agricultural and Food Chemistry·Jinwang LiGuofang Pang

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Methods Mentioned

BETA
urine collection
biopsies
biopsy
testosterone replacement therapy

Software Mentioned

JMP

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