Effects of Manganese Exposure on Olfactory Functions in Teenagers: A Pilot Study

PloS One
Emilia IannilliRoberto G Lucchini

Abstract

Long-term exposure to environmental manganese (Mn) affects not only attention and neuromotor functions but also olfactory functions of a pre-adolescent local population who have spent their whole life span in contaminated areas. In order to investigate the effect of such exposure at the level of the central nervous system we set up a pilot fMRI experiment pointing at differences of brain activities between a non-exposed population (nine subjects) and an exposed one (three subjects). We also measured the volume of the olfactory bulb as well as the identification of standard olfactory stimuli. Our results suggest that young subjects exposed to Mn exhibit a reduction of BOLD signal, subjective odor sensitivity and olfactory bulb volume. Moreover a region of interest SPM analysis showed a specifically reduced response of the limbic system in relation to Mn exposure, suggesting an alteration of the brain network dealing with emotional responses.

References

May 26, 1999·Environmental Health Perspectives·P J LandriganR W Amler
Oct 26, 2005·Environmental Science & Technology·Allison R Harris, Cliff I Davidson
Dec 8, 2007·Memory & Cognition·Johan Willander, Maria Larsson
Dec 21, 2011·Neurotoxicology·Khalid KhanPam Factor-Litvak
Jun 6, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Silvia ZoniRoberto Lucchini
Jun 12, 2012·Journal of Neuroscience Methods·J Ulrich SommerThomas Hummel
Mar 15, 2013·Current Opinion in Pediatrics·Silvia Zoni, Roberto G Lucchini
Sep 27, 2014·Environmental Health Perspectives·Youssef OulhoteMaryse F Bouchard

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Citations

Jan 9, 2019·Environmental Science and Pollution Research International·Carlotta AliasUmberto Gelatti
Sep 1, 2016·Environmental Health : a Global Access Science Source·Donna J CoetzeeIrina Stepanov
Sep 12, 2018·Journal of Occupational Medicine and Toxicology·Sabine Werner, Eberhard Nies
Dec 12, 2018·Nature Methods·Oscar EstebanKrzysztof J Gorgolewski
Dec 29, 2020·Frontiers in Neurology·Roberto G LucchiniAlessandro Padovani
Jul 17, 2020·NeuroImage·Kamalaker DadiArthur Mensch
Jun 1, 2021·Current Opinion in Toxicology·Hao Wang, Megumi T Matsushita

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Software Mentioned

Matlab
SPSS
AMIRA 3D
SPM8 Parametric Mapping
SPM

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