PMID: 6412595Oct 1, 1983Paper

Effects of mannitol on blood volume and central hemodynamics in patients undergoing cerebral aneurysm surgery

Anesthesia and Analgesia
A RudehillE Gordon

Abstract

The effects on hemodynamics and blood volume of 500 ml of 20% mannitol administered intravenously in 15 min at the beginning of cerebral aneurysm surgery have been studied in 10 patients. Measurements were made before the infusion of mannitol (control) and at 15-min intervals for 1 hr. Control measurements showed normal hemodynamic data, while blood volume was lower than normal (P less than 0.001). Immediately after the mannitol infusion cardiac index (25%; P less than 0.01), pulmonary capillary wedge pressure (48%; P less than 0.001), and blood volume (43%; P less than 0.001) increased. Thirty minutes after the mannitol infusion, blood volume had returned to control levels, while the cardiac index and pulmonary capillary wedge pressure decreased 21% (P less than 0.01 and P less than 0.05, respectively) below control levels. Forty-five minutes after the mannitol infusion, serum osmolality and urine volume remained high. Our data confirm the presence of hypovolemia in patients with subarachnoid hemorrhage and a transient increase in blood volume associated with the infusion of mannitol. The data emphasize, however, that the hemodynamic response is biphasic, with an initial increase in pulmonary capillary wedge pressure and cardi...Continue Reading

Associated Clinical Trials

Jan 22, 2010·John Bebawy, John Bebawy

Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·P AndersonG Ohman
May 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S G SorianoF A Burrows
Jan 1, 1992·Journal of Clinical Anesthesia·I A Herrick, A W Gelb
Jan 31, 2002·Anesthesiology·Kokila ThenuwaraJohnny E Brian
Oct 27, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W LinE M Haacke

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