PMID: 9178389Jun 1, 1997Paper

Effects of manual high-impulse CPR on myocardial perfusion during cardiac arrest in pigs

Resuscitation
Wilhelm BehringerAnton N Laggner

Abstract

The aim of the study was to compare the effect of a 30 and 50% duty cycle on coronary perfusion pressure (CPP) and end tidal carbon dioxide (ETCO2) and to determine whether a duty cycle of 30% can be achieved manually. After 3 min of ventricular fibrillation cardiac arrest, pigs were resuscitated in two groups with changing duty cycles every 3 min: group A starting with 50 and then 30%; and group B starting with 30 and then 50%. After administration of epinephrine, duty cycles in group A were 50 and then 30%, in group B initially 30% and then 50% Before administration of epinephrine, no significant differences in CPP between the 30 and 50% duty cycles were found; after epinephrine CPP increased with both duty cycles. ETCO2 did not vary before epinephrine; after epinephrine, there were statistically significant differences but there is doubt regarding the clinical relevance of these differences. Survival was 4/6 in group A and 3/5 in group B (NS). It is possible to perform a manual duty cycle of 30%. However, our data do not support the use of a 30% duty cycle during cardiopulmonary resuscitation (CPR).

References

Sep 1, 1989·Annals of Emergency Medicine·E R GonzalezE M Racht
Apr 1, 1989·Annals of Internal Medicine·J R WoodsM Tavel
Mar 10, 1988·The New England Journal of Medicine·J L FalkM H Weil
May 1, 1988·The Journal of Thoracic and Cardiovascular Surgery·J R NewtonC O Olsen
Jan 1, 1985·The American Journal of Emergency Medicine·A B SandersG A Ewy
Jan 1, 1984·Circulation·R F BellamyD C Pedersen

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Citations

Oct 4, 2000·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·P S AddisonC E Robertson
Nov 11, 2006·Cardiovascular Engineering·Gerrit J NoordergraafA Noordergraaf

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