Effects of margarines and butter consumption on lipid profiles, inflammation markers and lipid transfer to HDL particles in free-living subjects with the metabolic syndrome

European Journal of Clinical Nutrition
A C M GagliardiR D Santos

Abstract

Our purpose was to examine the effects of daily servings of butter, no-trans-fat margarine and plant sterol margarine, within recommended amounts, on plasma lipids, apolipoproteins (Apos), biomarkers of inflammation and endothelial dysfunction, and on the transfer of lipids to HDL particles in free-living subjects with the metabolic syndrome. This was a randomized, single-blind study where 53 metabolic syndrome subjects (62% women, mean age 54 years) received isocaloric servings of butter, no-trans-fat margarine or plant sterol margarine in addition to their usual diets for 5 weeks. The main outcome measures were plasma lipids, Apo, inflammatory and endothelial dysfunction markers (CRP, IL-6, CD40L or E-selectin), small dense LDL cholesterol concentrations and in vitro radioactive lipid transfer from cholesterol-rich emulsions to HDL. Difference among groups was evaluated by analysis of variance. There was a significant reduction in Apo-B (-10.4 %, P=0.043) and in the Apo-B/Apo-A-1 ratio (-11.1%, P=0.034) with plant sterol margarine. No changes in plasma lipids were noticed with butter and no-trans-fat margarine. Transfer rates of lipids to HDL were reduced in the no-trans-fat margarine group: triglycerides -42.0%, (P<0.001 vs ...Continue Reading

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Citations

Mar 28, 2013·European Journal of Clinical Nutrition·I A BrouwerM B Katan
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chiara Di LorenzoPatrizia Restani
Jan 3, 2015·Scandinavian Journal of Clinical and Laboratory Investigation·Eli HeggenSerena Tonstad
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Aug 18, 2021·Food Research International·Thaís Jordânia SilvaAna Paula Badan Ribeiro
Nov 4, 2021·Phytotherapy Research : PTR·Elyas Nattagh-EshtivaniAbed Ghavami

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