Effects of mast cells on the behavior of isolated heart fibroblasts: modulation of collagen remodeling and gene expression

Journal of Cellular Physiology
Angela de AlmeidaWayne Carver

Abstract

The extracellular matrix plays a critical role in the development and maintenance of the vertebrate heart. Changes in the accumulation, composition, or organization of the extracellular matrix are known to deleteriously affect heart function. Mast cells are thought to stimulate collagen expression and fibroblast proliferation accompanying fibrosis in some organs; however, the effects of mast cells on the heart interstitium are largely unexplored. The present studies were carried out to determine the effects of mast cells on isolated heart fibroblasts. Several in vitro assays were used including collagen gel contraction to examine the effects of mast cells on the function of isolated fibroblasts. Neonatal heart fibroblasts were cultured either with mast cells, mast cell-conditioned medium, or mast cell extracts, and their ability to contract collagen gels measured. Results from these experiments indicated that mast cells inhibit heart fibroblast migration and contraction of 3-dimensional collagen gels. Further experiments indicated that incubation of neonatal heart fibroblasts with extracts of mast cells altered the expression of collagen, matrix metalloproteases, and matrix receptors of the integrin family. These studies sugges...Continue Reading

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E BellC Merrill
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Feb 1, 1990·Circulation Research·K RakusanP Wicker
Feb 1, 1990·Experimental Cell Research·D GullbergK Rubin
Feb 1, 1987·Archives of Dermatology·F M Atkins, R A Clark
Jul 1, 1994·Journal of Molecular and Cellular Cardiology·C G BrillaK T Weber
Mar 15, 1997·The Journal of Clinical Investigation·J A Cairns, A F Walls
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M AbeH Kido
Mar 16, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A BertonF X Maquart
Oct 29, 2000·Cell Adhesion and Communication·S KanekarW Carver
May 1, 1998·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·S KanekarT K Borg
Sep 1, 1997·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·K T BorgT K Borg
Mar 1, 1997·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·V PatellaG Marone

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Citations

Sep 13, 2007·In Vitro Cellular & Developmental Biology. Animal·Xiaoyi ZhangWayne E Carver
Jul 13, 2006·Human Molecular Genetics·Feng-Chun YangD Wade Clapp
May 8, 2013·Cellular and Molecular Life Sciences : CMLS·Ping KongNikolaos G Frangogiannis
Jul 26, 2011·Journal of Cell Communication and Signaling·David B MurrayJoseph S Janicki
Oct 17, 2015·Journal of Cellular and Molecular Medicine·Zhengbo ShaoRen-Ke Li
Aug 26, 2006·Immunology and Allergy Clinics of North America·Ido BacheletYoseph A Mekori
Oct 22, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Stephen J ZoogGloria Juan
May 15, 2007·Immunological Reviews·Alicia C ReidRoberto Levi
Jul 3, 2013·Muscle & Nerve·Elise DuchesneClaude H Côté
Nov 13, 2004·Biochimica Et Biophysica Acta·Sadahiro KamiyaFumio Fukai
Sep 16, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ahmet AkgulKeith A Youker
Oct 12, 2015·World Journal of Pediatrics : WJP·Masaya SugimotoHideaki Senzaki
Jan 13, 2018·International Journal of Molecular Sciences·Scott P Levick, Alexander Widiapradja
Nov 16, 2002·Circulation Research·Mark A SussmanThomas K Borg
Sep 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Richard H KennedyJacob Joseph
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Gregory L BrowerJoseph S Janicki
Jul 30, 2018·Molecular Aspects of Medicine·Nikolaos G Frangogiannis

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