PMID: 11913335Mar 27, 2002Paper

Effects of maternal bilateral adrenalectomy on fetal rat cerebral cortex

The International Journal of Neuroscience
Necdet Demir, Ramazan Demir

Abstract

We investigated the effects of maternal bilateral adrenalectomy (ADX) on fetal rat cerebral cortices by assessing morphological and morphometrical parameters in light and electron microscopy studies. Pregnant adult rats underwent ADX on day 4 of gestation. Embryonic brain tissue from control and ADX groups were examined at each of the 10 embryonic stages, days 11 through 20 (E11-E20). Control and adrenalectomized pregnant females were sacrificed at each fetal stage, fetuses were removed from the uterine horns, and their brain tissue was processed for light and electron microscopy examination. In the ADX fetuses, the cortical laminae were thicker and overall cortex thickness was greater, but structural differentiation in the primitive cortical layers was delayed compared with that observed in controls. Apart from the differences in embryonic cell development noted at the structural level, we found no noticeable ultrastructural differences between the cerebral cortices of ADX and control fetuses at any of the stages studied. Overall, the ADX group's cortical tissue exhibited a greater degree of cell migration, an extended proliferative period in the cortical layers with the highest proportion of mitotic activity, and a greater th...Continue Reading

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Citations

Apr 1, 2006·Journal of Neurochemistry·Christian GuijarroOliver Kretz
Mar 5, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Lyudmila TrutAnastasiya Kharlamova

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