Effects of maternal dexamethasone therapy on fetal lung development in the rhesus monkey

American Journal of Perinatology
M J EngleP M Farrell

Abstract

A large body of evidence demonstrates that antenatal glucocorticoids can accelerate fetal lung maturation. The purpose of this study was to delineate the optimal dose of dexamethasone and to determine whether a single- or multiple-injection regimen of the same total dexamethasone dosage was more effective in accelerating pulmonary development. Pregnant rhesus monkeys were injected with varying doses of dexamethasone or vehicle as either a single-bolus injection or as four separate injections, each spaced 12 hours apart. All maternal treatments were begun exactly 72 hours prior to delivery, and all fetuses were delivered by cesarean section at 135 +/- 1 days gestation. When a single injection of dexamethasone was used, fetal liver weight increased in a dose-related fashion. Fetal and maternal cortisol and fetal blood glucose concentrations were also influenced by increasing dexamethasone dosages. Fetal pulmonary phospholipids, however, were unchanged at all steroid doses examined. Multiple injections of dexamethasone generally produced more pronounced effects, even though the total dexamethasone dose remained the same. Thus, liver weight and fetal and maternal cortisol, glucose, and insulin levels were significantly influenced b...Continue Reading

Citations

May 1, 1990·Brain Research. Developmental Brain Research·H UnoP M Farrell
Feb 15, 2005·American Journal of Respiratory and Critical Care Medicine·Becky J ProskocilEliot R Spindel
May 29, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·R GuilhermeD Mitanchez
Oct 27, 2007·Medical Hypotheses·Jason D PoleAlexander C Allen
Jul 11, 2008·Pediatric Pulmonology·Xenia I RoubliovaJan A Deprest
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·Christopher L Coe, Gabriele R Lubach
Nov 15, 2001·Seminars in Perinatology·K MurphyM Hannah
Dec 4, 2014·Journal of Developmental Origins of Health and Disease·C J D McKinlayJ E Harding
Apr 23, 2002·American Journal of Obstetrics and Gynecology·Fariba AghajafariMary Hannah
Mar 21, 2007·Obstetrical & Gynecological Survey·Clarissa BonannoRonald J Wapner
Apr 11, 2003·Clinical Obstetrics and Gynecology·Kellie Murphy, Fariba Aghajafari

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