Effects of maternal ethanol consumption and buspirone treatment on dopamine and norepinephrine reuptake sites and D1 receptors in offspring

Alcoholism, Clinical and Experimental Research
Roberta A GillespieMary J Druse

Abstract

Previously, it was shown that in utero ethanol exposure results in decreased serotonin (5-HT) and altered concentrations of 5-HT reuptake sites and 5-HT1A receptors in fetal and/or postnatal rats. Because fetal 5-HT is an essential trophic factor, this laboratory previously investigated the hypotheses that the early ethanol-associated 5-HT deficit contributed to subsequent development abnormalities in the serotonergic system and that the effects of the fetal 5-HT deficit could be prevented by maternal treatment with buspirone, a 5-HT1A receptor agonist. The present report determined the effects of maternal treatment with buspirone on two other neurotransmitter systems in the developing offspring of ethanol-fed dams: dopamine (DA) and norepinephrine reuptake sites and D1 receptors in postnatal day 19 offspring of control and ethanol-fed dams, that received daily injections of saline or 4.5 mg/kg buspirone. These investigations found that in utero ethanol exposure significantly decreased norepinephrine reuptake sites in the dorsomedial hypothalamic nucleus and anteroventral thalamic nucleus. There was also an ethanol effect in the dorsal raphe. D1 receptors were moderately increased (5-10% increase) in the striatum, and DA reupta...Continue Reading

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Citations

Sep 24, 1999·Neurotoxicology and Teratology·S Randall, J H Hannigan
Oct 8, 1999·Alcoholism, Clinical and Experimental Research·M J DruseJ L Eriksen
Feb 4, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Youssef SariYehia Mechref
Feb 1, 2005·Neurotoxicology and Teratology·Sonya K SobrianR Robert Holson
Aug 17, 2006·Neuroscience and Biobehavioral Reviews·John H HanniganRobert F Berman
Jan 13, 2015·Alcoholism, Clinical and Experimental Research·Alexander K ConverseMary L Schneider
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