Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring

Metabolism: Clinical and Experimental
R M LewisC N Hales

Abstract

Epidemiologic studies have demonstrated associations between low birth weight and increased rates of adult diseases such as hypertension and diabetes. Maternal iron restriction in the rat has been reported to both reduce birth weight and to elevate blood pressure at 40 days of age. The aim of the present study was to extend these findings to investigate the effects of maternal iron restriction on glucose tolerance and serum lipids, 2 important components of the metabolic syndrome, in adult offspring. Blood pressure, glucose tolerance, and serum lipids were measured in the 3-month-old offspring of iron-restricted dams. Rats were placed on control or iron-restricted diets 1 week before mating. At term, dams on the iron-restricted diet were anemic with decreased haemoglobin, red blood cell (RBC) count, hematocrit, and mean RBC volume compared with controls. Neonates from iron-restricted litters were more severely anemic than the dams. At birth, body weight was lower in the offspring of iron-restricted dams than in controls and was still decreased at 3 months of age. At this same age, systolic blood pressure was significantly elevated in the offspring of iron-restricted dams. Glucose tolerance was improved in the maternal iron-rest...Continue Reading

Citations

Jan 27, 2009·The British Journal of Nutrition·Ahamed IbrahimNasreen Z Ehtesham
Mar 27, 2013·The British Journal of Nutrition·Leontine C L van den HilVincent W V Jaddoe
Sep 5, 2002·The British Journal of Nutrition·Rohan M LewisC Nicolas Hales
Jul 8, 2003·The British Journal of Nutrition·S J M LisleA J Forhead
Apr 16, 2005·The Proceedings of the Nutrition Society·Lorraine Gambling, Harry J McArdle
Oct 17, 2003·The Journal of Physiology·Lorraine GamblingHarry J McArdle
Dec 20, 2012·International Journal of Nephrology·Euming Chong, Ihor V Yosypiv
May 3, 2013·Reproductive Biology and Endocrinology : RB&E·Ruth CornockSarah McMullen
Nov 13, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·John M RogersChristopher Lau
Aug 2, 2014·Journal of Developmental Origins of Health and Disease·A M Vaiserman
May 25, 2007·Archives of Physiology and Biochemistry·R Huw Jones, Susan E Ozanne
Mar 26, 2016·Frontiers in Physiology·Amanda N Sferruzzi-Perri, Emily J Camm
Feb 11, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Awatif M AbuzgaiaEdith Arany
Jun 5, 2016·Nutrition Reviews·Chang Cao, Mark D Fleming
Mar 31, 2017·Biogerontology·Daniella Duque-Guimarães, Susan Ozanne
Sep 6, 2017·Journal of Developmental Origins of Health and Disease·W D ReesH J McArdle
Apr 22, 2018·Clinical and Experimental Pharmacology & Physiology·Pierre HofsteeJames Sm Cuffe
Jun 17, 2004·Current Opinion in Nephrology and Hypertension·Julie R Ingelfinger
Aug 21, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Junlong ZhangChristopher D Byrne
Oct 31, 2007·Hypertension·Stephane L BourqueMichael A Adams
Oct 30, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D S Fernandez-TwinnS E Ozanne
Apr 15, 2010·The Biochemical Journal·Matthew J Warner, Susan E Ozanne
Oct 26, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert G Ellis-HutchingsJohn M Rogers
Jul 9, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M KomolovaM A Adams
Feb 1, 2006·Expert Review of Pharmacoeconomics & Outcomes Research·Roselle L Cripps, Susan E Ozanne
Apr 4, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·N R van den BroekJ P Neilson
Nov 23, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Donald A NovakMichael G Ross
May 1, 2007·The Proceedings of the Nutrition Society·Elizabeth C Cottrell, Susan E Ozanne
Sep 5, 2009·Pediatric Research·Keri A DrakePamela J Kling
Jan 15, 2010·The Journal of Nutrition·Parul Christian, Christine P Stewart
Jan 29, 2014·European Journal of Nutrition·Paulo C F MathiasLatifa Abdennebi-Najar
Nov 11, 2011·CNS Neuroscience & Therapeutics·Nikhil NihalaniJames L Megna
May 26, 2012·Biological Trace Element Research·Jinyan FuLiegang Liu
Sep 6, 2013·Reviews in Endocrine & Metabolic Disorders·Ramakrishnan Lakshmy
Aug 27, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·M WeltenVwv Jaddoe
Sep 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Junlong ZhangChristopher D Byrne
Jan 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Christopher Lau, John M Rogers
Oct 7, 2015·The Journal of Membrane Biology·L Mossa Al-HashimiH J McArdle
Oct 10, 2008·The American Journal of Clinical Nutrition·Marie-Jo A BrionAndy R Ness
Aug 19, 2011·Congenital Anomalies·Tetsuo OgawaSeiji Shioda
May 13, 2020·BMC Medicine·Andrew J ForgieBenjamin P Willing

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biological Trace Element Research
Cédric FossetHarry J McArdle
Clinical and Experimental Pharmacology & Physiology
J A WhitworthJ J Kelly
Environmental Health Perspectives
Kim BoekelheideJohn M Rogers
© 2021 Meta ULC. All rights reserved