PMID: 3756543Jul 1, 1986Paper

Effects of maternal nicotine injections on brain development in the rat: ornithine decarboxylase activity, nucleic acids and proteins in discrete brain regions

Brain Research Bulletin
T A SlotkinF J Seidler

Abstract

Fetal exposure to nicotine via maternal cigarette smoking produces intrauterine growth retardation and postnatal behavioral abnormalities. In this study, biochemical characteristics of brain development were compared in normal rats and in rats whose mothers received chronic nicotine injections throughout pregnancy. Nicotine exposure produced a persistent elevation of fetal ornithine decarboxylase activity preferentially in brain; in keeping with this selectivity, there was no evidence of the sparing of brain growth which ordinarily accompanies non-specific toxic insult. After birth, DNA synthesis was suppressed throughout the brain and there was a subsequent rebound during the phase of "catch-up" growth. Evidence was also obtained for regional selectivity of the adverse effects of maternal nicotine injections: the effects on DNA synthesis and levels were most profound in cerebellum (a region which matures postnatally) and growth-impairment was least evident in midbrain & brainstem, an early-maturing region. The maternal nicotine group also displayed desynchronization of the ontogenetic patterns of DNA, RNA and proteins in every brain region. These data indicate that maternally-injected nicotine compromises early biochemical eve...Continue Reading

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Citations

Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·S K SobrianL M Turner
Feb 22, 1991·Brain Research. Developmental Brain Research·B J McFarlandT A Slotkin
Sep 19, 1991·Brain Research. Developmental Brain Research·N I von ZieglerW Lichtensteiger
Sep 18, 1992·Brain Research. Developmental Brain Research·K BeekerS Pennington
Dec 16, 1994·Brain Research. Developmental Brain Research·S N PenningtonL W Means
Sep 1, 1986·Brain Research Bulletin·T A Slotkin, J Bartolome
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S C BondyG Ahmad
May 1, 1993·Neurotoxicology and Teratology·R B PaulsonJ O Paulson
Mar 1, 1993·Neurotoxicology and Teratology·E A ZahalkaT A Slotkin
Jul 18, 1997·Brain Research. Developmental Brain Research·J A CourtR H Perry
Nov 25, 1997·Brain Research. Developmental Brain Research·L W EcksteinS N Pennington
Jan 1, 1997·Brain Research Bulletin·C G CampbellT A Slotkin
Aug 26, 1998·Drug and Alcohol Dependence·P Levitt
Dec 11, 1997·Neurotoxicology and Teratology·J J ShackaS E Robinson
Aug 11, 1998·Neurotoxicology and Teratology·T S Roy, U Sabherwal
Nov 3, 2010·Developmental Psychology·Kimberly Andrews EspySandra A Wiebe
Jul 1, 1997·Archives of Environmental Health·J F OrlebekeF C Verhulst
Feb 20, 1999·Archives of Environmental Health·J F OrlebekeF C Verhulst
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May 7, 1999·Environmental Health Perspectives·T A Slotkin
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Aug 12, 2014·Current Problems in Pediatric and Adolescent Health Care·Sherry ZhouMichael Weitzman
Sep 15, 2014·Drug and Alcohol Dependence·Carmelinda A LongoAndra M Smith
Dec 3, 2014·Neurologic Clinics·Nadejda AlekseevaAlireza Minagar
Aug 30, 2014·Acta Paediatrica·Mikael EkbladLiisa Lehtonen
Apr 22, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Soo-Churl ChoHyo-Won Kim
Dec 1, 1988·The Journal of Pharmacy and Pharmacology·Y K Fung

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