Effects of Maternal Obesity on Fetal Programming: Molecular Approaches

Cold Spring Harbor Perspectives in Medicine
Caterina Neri, Andrea G Edlow

Abstract

Maternal obesity has become a worldwide epidemic. Obesity and a high-fat diet have been shown to have deleterious effects on fetal programming, predisposing offspring to adverse cardiometabolic and neurodevelopmental outcomes. Although large epidemiological studies have shown an association between maternal obesity and adverse outcomes for offspring, the underlying mechanisms remain unclear. Molecular approaches have played a key role in elucidating the mechanistic underpinnings of fetal malprogramming in the setting of maternal obesity. These approaches include, among others, characterization of epigenetic modifications, microRNA expression, the gut microbiome, the transcriptome, and evaluation of specific mRNA expression via quantitative reverse transcription polmerase chain reaction (RT-qPCR) in fetuses and offspring of obese females. This work will review the data from animal models and human fluids/cells regarding the effects of maternal obesity on fetal and offspring neurodevelopment and cardiometabolic outcomes, with a particular focus on molecular approaches.

Citations

Jun 29, 2017·Immunological Reviews·Craig McKenzieCharles R Mackay
Jun 22, 2017·Maternal & Child Nutrition·Elizabeth Marie WidenPam Factor-Litvak
Aug 15, 2018·The Journal of Physiology·Elisa Karen Silva RamosMichelle Andrade Lemos
Nov 7, 2018·American Journal of Physiology. Endocrinology and Metabolism·Eugenia Mata-GreenwoodPeter W Nathanielsz
Sep 6, 2019·Journal of Developmental Origins of Health and Disease·Amy R NicholsElizabeth M Widen
Mar 21, 2020·Pediatric Blood & Cancer·Roy KessousEyal Sheiner
Mar 15, 2019·Nutrients·Ana Laura de la GarzaAlberto Camacho
Sep 16, 2020·Nature Metabolism·Joji KusuyamaLaurie J Goodyear
Dec 21, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Luis Felipe León-AguilarFrancisco Bolaños-Jiménez
May 19, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P NakandakareP H C Rondó

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