Effects of maternal retinoic acid administration in a congenital diaphragmatic hernia rabbit model

Pediatric Pulmonology
Denis GallotJ A Deprest

Abstract

Maternal retinoid administration has beneficial effects on lung development in the nitrofen rodent toxic model of congenital diaphragmatic hernia (DH). We wanted to investigate the effects in a surgical model, where the retinoid signaling pathway is not primarily disrupted by the toxic agent. We created DH in fetal rabbits at day 23 of gestation, administrated to the does all trans-retinoic acid (ATRA) or vehicle (VHC) intramuscularly for 8 consecutive days and harvested normal and operated (DH) fetuses at 31 d (n = 7 in each group). Normal lungs exposed to ATRA had increased surfactant protein mRNA levels without change in type II pneumocyte density. There was no measurable effect on lung-to-body weight ratio and airway morphometry by ATRA. In DH lungs (DH/VHC) surfactant protein mRNA levels were increased, as well as the density of type II pneumocytes. When supplemented with ATRA (DH/ATRA) these parameters returned to normal (VHC). Cell proliferation or apoptosis were not influenced by ATRA supplementation. In conclusion, maternal ATRA supplementation does not affect gross anatomic, morphologic or proliferation indices in hypoplastic lungs related to surgically induced DH in rabbit. However, ATRA lowers surfactant protein exp...Continue Reading

References

Oct 1, 1990·The Journal of Clinical Investigation·A C MoessingerG T Kiu
Oct 3, 1985·The New England Journal of Medicine·E J LammerI T Lott
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Aug 1, 1995·Journal of Applied Physiology·M DolhnikoffM S Ludwig
Apr 1, 1995·Clinical and Experimental Pharmacology & Physiology·S B Hooper, R Harding
Jul 1, 1994·Journal of Pediatric Surgery·D O FauzaJ G Maksoud
Feb 1, 1994·Journal of Applied Physiology·E K VerbekenK P Van de Woestijne
Dec 1, 1996·Toxicology and Applied Pharmacology·E A TembeA G Renwick
Aug 5, 1998·The American Journal of Physiology·T KrarupE K Hoffmann
Oct 17, 1998·Pediatric Pulmonology·H IJsselstijn, D Tibboel
Nov 3, 1998·Pediatric Surgery International·D MajorR Cloutier
Dec 1, 2000·Human Reproduction·J WuJ Deprest
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·L G Dobbs, J A Gutierrez
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·B ThébaudJ R Bourbon
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Desmond Bohn
Jan 28, 2003·The American Journal of Pathology·Jörg MeyJohn J Greer
Feb 7, 2003·Journal of Applied Physiology·Marcus G DaveyAlan W Flake
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Jorge A GutierrezLeland G Dobbs
Mar 7, 2003·Pediatric Research·John J GreerBernard Thebaud
Jul 2, 2003·Mechanisms of Development·Claire ChazaudRichard Mollard
Jan 20, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Randal P BabiukJohn J Greer
Mar 17, 2004·Gene·Julie Bastien, Cécile Rochette-Egly
Jun 19, 2004·American Journal of Respiratory Cell and Molecular Biology·Katherine DahlinLeland Dobbs
Jun 24, 2004·Journal of Pediatric Surgery·X RoubliovaJ Deprest
Sep 8, 2004·Current Topics in Developmental Biology·Malcolm Maden
Jun 28, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Denis GallotVincent Sapin
Jul 30, 2005·Seminars in Perinatology·Robbert Rottier, Dick Tibboel
Nov 15, 2005·Pediatric Surgery International·Sandra MontedonicoPrem Puri
Jan 25, 2006·Investigative Ophthalmology & Visual Science·Frédéric ChiambarettaVincent Sapin
Feb 24, 2006·Biology of the Neonate·Salome Gonzalez-ReyesJuan A Tovar
May 31, 2006·Biology of the Neonate·Jean-Claude FauchèreThomas Stallmach
Jun 24, 2006·Biochemical and Biophysical Research Communications·Geoffroy MarceauVincent Sapin
Dec 21, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D GallotD Lemery
Apr 17, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·David E Kling, Jay J Schnitzer
Aug 7, 2007·PLoS Medicine·Olivier BoucheratJacques R Bourbon
Dec 1, 2007·Pediatric Research·Chung-Ming ChenChing-Ying Yeh
Mar 1, 2007·Animal : an International Journal of Animal Bioscience·K CosteV Sapin

❮ Previous
Next ❯

Citations

Dec 3, 2014·Seminars in Fetal & Neonatal Medicine·Cerine JeantyTippi C MacKenzie
Nov 25, 2014·Multidisciplinary Respiratory Medicine·Gloria PelizzoValeria Calcaterra
May 10, 2011·Revue des maladies respiratoires·A LabbéP-J Déchelotte
Apr 13, 2011·Revue des maladies respiratoires·K Coste, A Labbe
Mar 27, 2018·Prenatal Diagnosis·Amélie DelabaereDenis Gallot
Aug 5, 2017·Disease Models & Mechanisms·Gabrielle KardonWendy K Chung
Nov 25, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karen CosteVincent Sapin
Feb 6, 2017·Prenatal Diagnosis·Amélie DelabaereDenis Gallot
May 2, 2018·Pediatric Surgery International·Mariatu A VerlaOluyinka O Olutoye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis