Effects of maternal smoking and exposure to methylmercury on brain-derived neurotrophic factor concentrations in umbilical cord serum.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Stefan SpulberSandra Ceccatelli

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin essential for neuronal survival and differentiation. We examined the concentration of BDNF in cord serum from newborns exposed to methylmercury (MeHg) and polychlorinated biphenyls (PCB) in utero by maternal consumption of whale meat. The cohort consisted of 395 singleton births (206 boys and 189 girls), gestational age ranging from 38 to 42 weeks. Serum BDNF was measured by sandwich ELISA. Maternal smoking habits and other relevant factors were obtained by interviewing the mothers. The exposure to MeHg was estimated from Hg concentrations in cord blood, whereas exposure to PCB was estimated based on maternal serum concentrations. Only MeHg exposure affected the serum BDNF, which decreased in a concentration-dependent manner in girls born to nonsmoking mothers. Maternal smoking significantly increased BNDF in girls but not in boys. For further statistical analyses, we used the serum BDNF concentration as a continuous outcome variable in supervised regression models. Serum BDNF concentration increased with gestational age, increased by maternal smoking, decreased slightly with MeHg exposure, and maternal smoking enhanced the decrease in serum BDNF induced by MeHg exposur...Continue Reading

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Citations

Aug 25, 2015·Environmental Research·Frederica PereraDeliang Tang
May 29, 2016·Progress in Neurobiology·Marta C AntonelliStefan Spulber
Jan 14, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Despina D BrianaAriadne Malamitsi-Puchner
May 4, 2017·Development and Psychopathology·Akhgar GhassabianEdwina H Yeung
May 30, 2017·Mediators of Inflammation·Rafael Coelho MagalhãesAna Cristina Simões E Silva
Feb 6, 2017·Frontiers in Neuroscience·Natascia GuidaLuigi Formisano
Jun 8, 2017·Archives of Gynecology and Obstetrics·Qian-Ying CaiXin-Jun Yang
Feb 15, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alessio D'AngeloMarisa Patrizia Messina

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