Effects of MDL 72222 and methiothepin on carotid vascular responses to 5-hydroxytryptamine in the pig: evidence for the presence of "5-hydroxytryptamine1-like" receptors

Naunyn-Schmiedeberg's Archives of Pharmacology
P R SaxenaP D Verdouw

Abstract

The present study concerns the effects of MDL 72222 (0.5 mg X kg-1, i.v.), a 5-hydroxytryptamine3 (5-HT3) receptor antagonist, and methiothepin (1.0 mg X kg-1, i.v.), an antagonist of both 5-HT2 and "5-HT1-like" receptors, on the responses to local infusions of 5-HT (2.0 micrograms X kg-1 X min-1) on the total common carotid artery blood flow and its complete distribution in anaesthetized pigs. As reported earlier, more than 80% of the carotid blood bypassed the capillary circulation via cranial arteriovenous anastomoses, while approximately 15% and 2% was distributed to the extracerebral structures and brain, respectively. The total carotid blood flow did not change or was moderately reduced by 5-HT, but the amine consistently caused a 85% reduction in arteriovenous anastomotic blood flow and a 5-fold increase in blood flow to the extracerebral tissues, mainly the skin and ears. The colour of the skin and ears changed to bright pink. Complete recovery from the effects of 5-HT was observed once the infusion was stopped. MDL 72222 and methiothepin did not themselves affect carotid haemodynamics. The responses to 5-HT were not modified by MDL 72222 except that the reduction of the total carotid blood flow by 5-HT was augmented. I...Continue Reading

References

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Citations

Jan 1, 1991·Journal of Neurology·E J Mylecharane
Feb 6, 1990·European Journal of Pharmacology·A ContiP Biglioli
Dec 4, 1990·European Journal of Pharmacology·D van Heuven-NolsenP R Saxena
May 1, 1995·Pharmacology & Therapeutics·P R Saxena
May 1, 1989·Trends in Pharmacological Sciences·P R Saxena, M D Ferrari
Feb 1, 1991·British Journal of Pharmacology·I Sahin-ErdemliP Schoeffter
Jan 1, 1991·Journal of Neurology·P R Saxena, M O Den Boer
Jan 1, 1989·Fundamental & Clinical Pharmacology·P R Saxena
Aug 1, 1992·Cephalalgia : an International Journal of Headache·P R Saxena, M D Ferrari
Jan 1, 1989·Cephalalgia : an International Journal of Headache·P R SaxenaP D Verdouw

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