Effects of meal timing on tumor progression in mice

Life Sciences
M W WuF Lévi

Abstract

Meal timing can reset circadian clocks in peripheral tissues. We investigated the effects of such non-photic entrainment on tumor growth rate. Two experiments involved a total of 61 male B6D2F(1) mice synchronized with an alternation of 12 h of light (L) and 12 h of darkness (D) (LD12:12). Mice were randomly allocated to have access to food ad libitum, or restricted to 4 or 6 h during L or D. Rest-activity and body temperature, two circadian outputs, were monitored with an intra-peritoneal sensor. Glasgow osteosarcoma was inoculated into both flanks of each mouse ten days after meal timing onset. Before tumor inoculation, meal timing during D amplified the 24-h rhythms in rest-activity and body temperature with minimal phase alteration as compared to ad libitum feeding. Conversely, meal timing during L induced dominant 12-h or 8-h rhythmic components in activity, nearly doubled the 24-h amplitude of body temperature and shifted its acrophase (time of maximum) from approximately mid-D to approximately mid-L. Thirteen days after tumor inoculation, mean tumor weight (+/- SEM, mg) was 1503 +/- 150 in ad libitum mice, 1077 +/- 157 in mice fed during D and 577 +/- 139 in mice fed during L (ANOVA, p < 0.0001). Overall survival was pro...Continue Reading

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Citations

Apr 6, 2006·Cancer Causes & Control : CCC·Elizabeth FilipskiFrancis Lévi
Apr 7, 2005·Journal of the National Cancer Institute·Elisabeth FilipskiFrancis Lévi
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·F LéviP Innominato
Sep 26, 2012·Journal of Innate Immunity·P D MavroudisI P Androulakis
Mar 29, 2014·Journal of Translational Medicine·Jag SunderramIoannis P Androulakis
Jan 9, 2014·Chronobiology International·Véronique Pasquale RocheFrancis Albert Lévi
Jun 14, 2014·Chronobiology International·Francis LéviUNKNOWN ARTBC Chronotherapy Group
Jun 11, 2014·Annals of Medicine·Pasquale F InnominatoFrancis A Lévi
Apr 26, 2012·Experimental Animals·Kohei KawakamiToru Nabika
Oct 17, 2009·Mutation Research·Elisabeth FilipskiFrancis Lévi
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Oct 1, 2013·Ageing Research Reviews·Oren Froy
Jan 1, 2010·Integrative Cancer Therapies·Elisabeth Filipski, Francis Lévi
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Sep 9, 2020·Nature Reviews. Cancer·Kenichiro Kinouchi, Paolo Sassone-Corsi
Nov 3, 2004·Cancer Research·Elisabeth FilipskiLévi Francis
Mar 7, 2021·Biology·Sonal A Patel, Roman V Kondratov

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