Effects of mechanical and chemical stimulation of fine muscle afferents upon primate spinothalamic tract cells

The Journal of Physiology
R D ForemanW D Willis

Abstract

1. Injections of algesic chemicals were made into the arterial circulation of the triceps surae muscles in anaesthetized monkeys. 2. The responses of a sample of primary muscle afferents suggest that what is known about the activation of muscle afferents in the cat by algesic agents applies also to the monkey. One exception to this is the activation of many group I afferents by KCl in the monkey, but not in the cat. 3. Many spinothalamic tract cells were powerfully excited by the intra-arterial injection of algesic chemicals (bradykinin, 5-hydroxytryptamine (5-HT), KCl) in preparations in which the hind limb was denervated except for the nerves to the triceps surae muscles. The excitatory action of bradykinin had a slower time course than did that of 5-HT or KCl. 4. A number of the spinothalamic tract cells which failed to respond to chemical activation of muscle afferents were located in lamina I of the spinal cord. 5. Repeated injections of bradykinin produced similar responses, whereas the effects of 5-HT injections showed marked tachyphylaxis. 6. No evidence was obtained that activation of muscle spindle afferents by succinylcholine injections resulted in the excitation of spinothalamic tract neurones in the population samp...Continue Reading

Citations

Feb 12, 1999·Brain Research. Brain Research Reviews·G W Lu, W D Willis
Aug 1, 1985·Brain Research·D Albe-FessardW D Willis
Jan 1, 1981·Pharmacology & Therapeutics·Donna L Hammond, Tony L Yaksh
Jul 6, 2011·The Journal of Physiology·Saad S NagiDavid A Mahns
Jan 1, 1988·Annals of the New York Academy of Sciences·W D Willis
Jun 15, 2014·Journal of Manipulative and Physiological Therapeutics·William R ReedCynthia R Long
Sep 26, 2006·Scandinavian Journal of Rheumatology. Supplement·T Graven-Nielsen
Oct 15, 1989·The Journal of Comparative Neurology·A V Apkarian, C J Hodge
May 1, 1982·The Journal of Comparative Neurology·L H HaberW D Willis
Aug 5, 2006·Cephalalgia : an International Journal of Headache·S AshinaR Jensen
Jul 20, 2017·Physiological Reports·Shafaq SikandarAnthony H Dickenson
Jan 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·W D Willis, K N Westlund
Dec 15, 1979·The Journal of Comparative Neurology·W D WillisR B Leonard
Dec 15, 1979·The Journal of Comparative Neurology·A E ApplebaumW D Willis
Mar 1, 1982·Pflügers Archiv : European journal of physiology·A SatoR F Schmidt
Jan 10, 1981·The Journal of Comparative Neurology·G J GieslerW D Willis
Feb 1, 1985·Journal of Neurosurgery·K H LeeW D Willis
Feb 19, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W D Willis
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M Degtyarenko, M P Kaufman
Oct 3, 2001·Physiological Reviews·S C Gandevia
Oct 24, 2020·AJNR. American Journal of Neuroradiology·C D Norris, N A Koontz

Related Concepts

Metazoa
Anthropoidea
Bradykinin, (3-D-Pro)-Isomer
Potentials, Event-Related
Macaca fascicularis
Muscle
Neurons
Afferent Neuron
Physical Stimulation
Slow-K

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