PMID: 11311513Apr 20, 2001Paper

Effects of mechanical compression on hypertrophic scars: prostaglandin E2 release

Burns : Journal of the International Society for Burn Injuries
F RenòMario Cannas

Abstract

An alteration in the normal process of tissue repair can lead to the formation of hypertrophic scars. The best prevention and control of hypertrophy, especially in burn scars, is achieved using elastocompression, through a mechanism not yet clarified. Various studies have shown that mechanical compression induces the release of prostaglandin E2 (PGE2) and that PGE2 increases the expression of collagenases. In this study, we evaluated the effect of mechanical compression in vitro on PGE2 release in human normotrophic (NS) and hypertrophic (HS) burn scars. PGE2 basal levels in HS were significantly lower than those present in NS, and compression induced a significant increase in the release of PGE2 in HS scar in remission (7.2 times basal level) and active stages (5.88 times basal level). This increase seemed to be only partially IL-1beta-dependent. These data suggest a role for PGE2 in the process of hypertrophy remission induced by pressure therapy.

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Citations

Mar 17, 2004·Toxicology and Applied Pharmacology·Gerardo RamosStephen E Ullrich
Apr 9, 2010·Plastic and Reconstructive Surgery·Caglayan YagmurEthem Guneren
Jul 29, 2006·Arthritis Research & Therapy·Marjolaine GossetClaire Jacques
Jul 24, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Sameena HassanPeter Brooks
Apr 29, 2014·Burns : Journal of the International Society for Burn Injuries·Anna I ArnoMarc G Jeschke
Nov 27, 2007·Burns : Journal of the International Society for Burn Injuries·Amélie BourgetE Patricia Egerszegi
Nov 11, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M FeronT Haumont
Sep 3, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Filippo RenòMario Cannas
Jan 18, 2006·Burns : Journal of the International Society for Burn Injuries·Lisa Macintyre, Margot Baird
Sep 26, 2013·Case Reports in Orthopedics·Ismail TurkmenKorhan Ozkan
Jul 31, 2010·Mediators of Inflammation·Wen-Hsiang SuPeng-Hui Wang
Jun 10, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Patricia A SharpDawn Rothchild
Apr 12, 2003·American Journal of Clinical Dermatology·Tina S Alster, Elizabeth L Tanzi
Mar 14, 2017·Scars, Burns & Healing·Rory Boyd McGoldrickMaxwell Murison
Dec 24, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Bonnie C CarneyJeffrey W Shupp
Jul 6, 2017·Frontiers in Medicine·Zrinka Bukvić MokosBranka Marinović
Jul 31, 2021·Advances in Wound Care·Bo YuanXi-Qiao Wang
Oct 28, 2008·Burns : Journal of the International Society for Burn Injuries·Monica C T BloemenEsther Middelkoop

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