Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies

Bone & Joint Research
M LiYanqi Yang

Abstract

Many in vitro studies have investigated the mechanism by which mechanical signals are transduced into biological signals that regulate bone homeostasis via periodontal ligament fibroblasts during orthodontic treatment, but the results have not been systematically reviewed. This review aims to do this, considering the parameters of various in vitro mechanical loading approaches and their effects on osteogenic and osteoclastogenic properties of periodontal ligament fibroblasts. Specific keywords were used to search electronic databases (EMBASE, PubMed, and Web of Science) for English-language literature published between 1995 and 2017. A total of 26 studies from the 555 articles obtained via the database search were ultimately included, and four main types of biomechanical approach were identified. Compressive force is characterized by static and continuous application, whereas tensile force is mainly cyclic. Only nine studies investigated the mechanisms by which periodontal ligament fibroblasts transduce mechanical stimulus. The studies provided evidence from in vitro mechanical loading regimens that periodontal ligament fibroblasts play a unique and dominant role in the regulation of bone remodelling during orthodontic tooth mo...Continue Reading

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Citations

Nov 17, 2020·Advanced Healthcare Materials·Sanja AveicHorst Fischer
Dec 5, 2020·Bone & Joint Research·Pablo A SlullitelGeorge Grammatopoulos
Jun 24, 2021·Journal of Dental Research·Y XieL Chen
Aug 31, 2020·The Journal of Prosthetic Dentistry·Steven J Sadowsky, John B Brunski
Aug 11, 2020·Journal of Oral Biology and Craniofacial Research·Sutiwa BenjakulChidchanok Leethanakul
Sep 14, 2021·Frontiers in Bioengineering and Biotechnology·Changyun SunUwe Baumert

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