Effects of mechanical load on flow, volume and pressure delivered by high-frequency percussive ventilation

Respiratory Physiology & Neurobiology
U LucangeloA Gullo

Abstract

High-frequency percussive ventilation (HFPV) has proved its unique efficacy in the treatment of acute respiratory distress, when conventional mechanical ventilation (CMV) has demonstrated a limited response. We analysed flow (V(dot)), volume (V) and airway pressure (Paw) during ventilation of a single-compartment mechanical lung simulator, in which resistance (R) and elastance (E) values were modified, while maintaining the selected ventilatory settings of the HFPV device. These signals reveal the physical effect of the imposed loads on the output of the ventilatory device, secondary to constant (millisecond by millisecond) alterations in pulmonary dynamics. V(dot), V and Paw values depended fundamentally on the value of R, but their shapes were modified by R and E. Although peak Paw increased 70.3% in relation to control value, mean Paw augmented solely 36.5% under the same circumstances (maximum of 9.4 cm H2O). Finally, a mechanism for washing gas out of the lung was suggested.

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Citations

Sep 22, 2007·Intensive Care Medicine·Jérôme Allardet-ServentLaurent Papazian
Mar 13, 2012·Revue des maladies respiratoires·G Riffard, M Toussaint
Feb 24, 2006·Respiratory Medicine·Stefano NavaSerena Cirio
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Mar 9, 2005·Critical Care Medicine·Ali Salim, Matthew Martin
Oct 30, 2013·Physiological Measurement·E FornasaA Accardo
Apr 16, 2011·Physiological Measurement·F RiscicaA Accardo
Feb 2, 2006·Respiratory Physiology & Neurobiology·U LucangeloA Gullo

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