Effects of medium-chain triglycerides, long-chain triglycerides, or 2-monododecanoin on fatty acid composition in the portal vein, intestinal lymph, and systemic circulation in rats.

JPEN. Journal of Parenteral and Enteral Nutrition
Yi-Qian Nancy YouBruce R Bistrian

Abstract

Fatty acid absorption patterns can have a major impact on the fatty acid composition in the portal, intestinal lymph, and systemic circulation. This study sought to determine the effects of long-chain triglycerides (LCT), medium-chain triglycerides (MCT), and 2-monododecanoin (2mono) on intestinal fatty acid composition during continuous feeding over a brief period. The lipid sources were 100% LCT, 100% MCT, a 50:50 mixture of LCT and MCT (LCT/MCT), and a 50:50 mixture of LCT and 2mono (LCT/2mono). A total of 27 rats were randomly given 1 of the 4 diets at 200 kcal/kg/d, with 30% of total calories from lipids over 3 hours. MCT significantly increased each of the medium-chain fatty acids (C6:0, C8:0, and C10:0) as free fatty acids in the portal vein and about 10%/mol of C10:0 as triglycerides in the lymph compared with the other groups. There was significantly less C10:0 in lymphatic triglycerides with LCT/MCT than with MCT, but more than in the LCT and LCT/2mono diets. MCT also significantly increased the contents of C16:0, C18:0, C18:1, and C20:4 in the lymphatic triglycerides compared with all other groups including LCT/MCT. The amount of linoleic acid (C18:2) in lymphatic triglycerides followed the relative amounts of this f...Continue Reading

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Citations

May 11, 2010·Physiology & Behavior·S D PoppittA-T McGill
Oct 30, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Margot FijlstraEdmond H H M Rings
Mar 23, 2019·International Journal of Molecular Sciences·Judith RadloffSalah Amasheh
Apr 2, 2014·Language, Speech, and Hearing Services in Schools·Kathryn CroweTeresa Y C Ching
Nov 26, 2010·American Journal of Physiology. Endocrinology and Metabolism·Sébastien M LabbéAndré C Carpentier
Sep 3, 2014·Physiology·Daniel Konrad, Stephan Wueest
Dec 10, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Sabri Ahmed RialCatherine Mounier
Feb 12, 2021·Ultrasonics Sonochemistry·Harsh B JadhavUday S Annapure
Apr 3, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Siniša ĐuraševićZoran Todorović
Nov 14, 2020·International Journal of Molecular Sciences·Carmen J Pastor-MaldonadoJosé A Sánchez-Alcázar
Jul 14, 2021·The Journal of Nutrition·Kirsty M McKenzieMichael R Skilton
Sep 29, 2021·The British Journal of Nutrition·Étienne Myette-CôtéStephen C Cunnane

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