PMID: 9664141Jul 17, 1998Paper

Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells

Melanoma Research
D N HuJ E Roberts

Abstract

The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied. The melanoma cells were plated into 24-well plates. Melatonin, its 6-hydroxy or 6-chloro derivative, serotonin, tryptophan or kynurenine was added to the medium in concentrations of 0.001 to 1000 nM. After 5 days the cells were detached, counted, and compared with the controls. Melatonin inhibited the growth of uveal melanoma cell lines in a dose-dependent manner (0.1-10 nM). This growth inhibition occurred at concentrations of melatonin (2 nM) found in human aqueous humour. The melatonin derivatives also inhibited the growth of uveal melanoma cells; 6-chloromelatonin was more potent than melatonin and 6-hydroxymelatonin was the least active (6-chloromelatonin > melatonin > 6-hydroxymelatonin). The precursors of melatonin (tryptophan and serotonin) and the abnormal metabolite of tryptophan (kynurenine) did not inhibit the growth of the melanoma cells, indicating that changes to the metabolic processes of melatonin may play a role in the pathogenesis of uveal melanoma.

Citations

Dec 18, 2001·Journal of Photochemistry and Photobiology. B, Biology·J E Roberts
May 16, 2000·Occupational and Environmental Medicine·V RafnssonH Tulinius
Feb 4, 2005·International Journal of Dermatology·Claudia C RamirezRobert S Kirsner
Jul 31, 2003·Journal of Pineal Research·Yoichi KobayashiBunpei Ishizuka
Dec 4, 2003·Clinical & Experimental Ophthalmology·Hayyam KiratliSevgül Bilgiç
Mar 11, 2004·Journal of Pineal Research·Ana Luisa KadekaroAna Maria de L Castrucci
Jul 5, 2006·The FEBS Journal·S R Pandi-PerumalR Hardeland
Sep 26, 2008·Integrative Cancer Therapies·Venkataramanujan SrinivasanDaniel P Cardinali
May 27, 2003·Journal of Cellular Physiology·Andrzej SlominskiJacobo Wortsman
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman
Jan 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrzej SlominskiDesmond J Tobin
Mar 29, 2003·Journal of Pineal Research·Andrea Vieira SouzaAna Maria de Lauro Castrucci
Dec 4, 2019·Journal of Gastrointestinal Cancer·Shahrokh IravaniKeivan Majidzadeh-A

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