PMID: 9181520Mar 1, 1997Paper

Effects of melatonin on mammary gland lesions in transgenic mice overexpressing N-ras proto-oncogene

Journal of Pineal Research
M D MediavillaE J Sánchez Barceló

Abstract

The oncostatic effects of melatonin on the mammary gland have been studied in transgenic mice carrying the N-ras proto-oncogene under the control of the MMTV-LTR. Female (4-week-old) virgin mice with positive transgenic pedigrees were injected with melatonin (200 micrograms/mouse/ day, five times a week) or vehicle late in the evening. After 5 months of treatment, animals were sacrificed and the mammary glands were dissected for whole mounts, histology, and immunohistochemical analysis with a mouse monoclonal antibody specific for N-ras protein. Mammary glands of control transgenic mice showed different densities of hyperplastic alveolar nodules (HANs) consisting primarily of dysplastic epithelial cells with nuclear atypia and prominent nucleoli. The epithelial cells of HANs showed a high expression of N-ras while no immunostaining was detected in the unaffected mammary parenchyma. Only one (10%) of the control transgenic mice presented an infiltrating ductal carcinoma with the neoplastic cells overexpressing N-ras protein. The mammary glands of melatonin treated mice had a lower density of HANs, absence of epithelial dysplastic cells, and weak immunostaining of N-ras protein in comparison to the vehicle-treated group. None of ...Continue Reading

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Citations

Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Vladimir N AnisimovAnatoly I Yashin
Jul 2, 2008·Breast Cancer Research and Treatment·Ahmet KorkmazRussel J Reiter
Jun 7, 2003·Critical Reviews in Oncology/hematology·Vladimir N Anisimov
May 23, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Sarah Q ToColin D Clyne
Jan 19, 2006·Journal of Women's Health·Alessandra BujaFrancesca Dominici
Sep 26, 2012·Cellular and Molecular Life Sciences : CMLS·Sara ProiettiMariano Bizzarri
Apr 9, 2005·Journal of Pineal Research·Emilio J Sánchez-BarcelóCarolina Alonso-González
Apr 26, 2006·Journal of Pineal Research·C Martínez-CampaE J Sánchez-Barceló
May 2, 2006·Cancer Detection and Prevention·Samuel CosEmilio J Sánchez-Barceló
Jun 14, 2005·Cancer Letters·Samuel CosEmilio J Sánchez-Barceló
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir N AnisimovIrina A Vinogradova
Apr 15, 2000·Frontiers in Neuroendocrinology·S Cos, E J Sánchez-Barceló
Jan 26, 2013·International Journal of Molecular Sciences·Giuseppe Di BellaLuigi Di Bella
Jun 6, 2012·Oncology Reports·Giulia Costanza LeonardiConcettina Fenga
Sep 19, 2020·Cancer Cell International·Mohammad Hossein MehrzadiSaeed Mehrzadi

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