Effects of melatonin on thymic and oxidative stress dysfunctions during Trypanosoma cruzi infection

Journal of Pineal Research
Vânia BrazãoJosé C Prado

Abstract

Although the exact etiology of Chagas disease is not completely elucidated, thymic atrophy and oxidative stress are believed to be important contributors to the pathogenesis during acute Trypanosoma cruzi (T. cruzi) infection. We hypothesized that exogenous melatonin, administered by gavage (5 mg/kg, p.o., gavage) to young (5 weeks old) and middle-aged (18 months old) male Wistar rats, would modulate thymic oxidative damage and reverse the age-related thymus regression during T. cruzi acute infection. Increased levels of superoxide anion (O2- ) were detected in the thymus of infected animals, and treatment with melatonin reverted this response. We found reduced TBARS levels as well as a significant increase in superoxide dismutase (SOD) activity in the thymus of all middle-aged melatonin-treated animals, infected or not with T. cruzi. Furthermore, melatonin increased the thymic expression of SOD1 and SOD2 in middle-aged control animals. Nox2 expression was not affected by melatonin treatment in young or middle-aged animals. Melatonin reverted the age-related thymic regression as revealed by the increase in thymus weight, total number of thymocytes, and reduction in age-related accumulation of double-negative thymocytes. This is...Continue Reading

References

Jan 1, 1994·Life Sciences·C PieriF Marcheselli
Jan 1, 1993·Journal of Pineal Research·G J Maestroni
Aug 8, 1995·Mechanisms of Ageing and Development·M L Thoman
Mar 1, 1995·Experimental Gerontology·A D BolzánM S Bianchi
Jun 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I AntolínA Menéndez-Peláez
Jun 1, 1996·Immunology Today·A J George, M A Ritter
May 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D PozoJ M Guerrero
Jul 15, 1998·Journal of Neuroimmunology·M Rafii-El-IdrissiJ M Guerrero
Aug 12, 2000·Journal of Clinical Immunology·R Aspinall, D Andrew
Sep 12, 2000·Journal of Pineal Research·Q YuD G Osmond
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Juan MucciOscar Campetella
Dec 12, 2002·Cellular and Molecular Life Sciences : CMLS·J C MayoC Rodriguez
Jun 6, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Russel J Reiter
Nov 18, 2003·Cellular and Molecular Life Sciences : CMLS·A Carrillo-VicoJ M Guerrero
Mar 17, 2004·Current Opinion in Immunology·Frances T HakimRonald E Gress
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joy A PhillipsMarilyn L Thoman
Dec 14, 2004·Frontiers in Neuroendocrinology·M Mila Macchi, Jeffrey N Bruce
Feb 24, 2005·Journal of Pineal Research·Ying-Hui Wu, Dick F Swaab
Oct 12, 2005·Endocrine·Antonio Carrillo-VicoRussel J Reiter
Mar 3, 2007·International Journal of Cardiology·Leonilda Banki MaçaoTânia Silva Fröde
Mar 6, 2007·Cellular and Molecular Life Sciences : CMLS·M C NaranjoP Molinero
Apr 19, 2007·Journal of Pineal Research·Fabrícia Helena SantelloJosé Clóvis do Prado
Jun 3, 2008·Journal of Pineal Research·Marina Sánchez-HidalgoCatalina Alarcón de la Lastra Romero
May 29, 2009·The Journal of Nutrition·Carmen P WongEmily Ho
Aug 11, 2010·Biochemical Pharmacology·Flavia RadognaLina Ghibelli
Jul 15, 2011·Journal of Pineal Research·Annia GalanoRussel J Reiter
Sep 29, 2011·The Journal of Pathology·Monisha Dhiman, Nisha Jain Garg
Jan 17, 2012·Molecular and Cellular Endocrinology·Radomir M SlominskiAndrzej T Slominski
Jun 26, 2012·Journal of Pineal Research·José L MaurizJavier González-Gallego
Jun 26, 2012·The Journal of Clinical Investigation·Claudia N PaivaMarcelo T Bozza
Sep 25, 2012·Journal of Pineal Research·Annia GalanoRussel J Reiter
Oct 19, 2012·Seminars in Immunopathology·Fabiana S MachadoNisha J Garg
Jul 6, 2013·Acta Microbiologica Et Immunologica Hungarica·György Csaba
Jul 24, 2013·Age·Rita RezzaniLuigi Fabrizio Rodella
Jul 31, 2013·Journal of Pineal Research·Juan R CalvoM D Maldonado
Oct 11, 2013·Frontiers in Immunology·Donald B Palmer

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