Effects of Membrane Defects and Polymer Hydrophobicity on Networking Kinetics of Vesicles

Langmuir : the ACS Journal of Surfaces and Colloids
Yan XiaMu-Ping Nieh

Abstract

The kinetics of clustering unilamellar vesicles induced by inverse Pluronics [poly(propylene oxide)m-poly(ethylene oxide)n-poly(propylene oxide)m, POm-EOn-POm] was investigated via experiments and molecular dynamic simulations. Two important factors for controlling the networking kinetics are the membrane defects, presumably located at the interfacial region between two lipid domains induced by acyl chain mismatch, and the polymer hydrophobicity. As expected, the clustering rate increases significantly with increasing bilayer defects on the membrane where the insertion of PPO is likely to take place because of the reduced energy barrier for the insertion of PO. The hydrophobic interaction between the PO blocks and membranes with the defects region dictates the "anchoring" kinetics, which is controlled by the association-dissociation of PO with the lipid membrane. As a result, the dependence of clustering rate on polymer concentration is strongly influenced by the hydrophobicity of the PO blocks. Nevertheless, longer PO blocks show stronger association with the membrane, resulting in faster consumption of the "active" sites made of these defect regions (causing mostly "invalid" insertions) with increasing polymer concentration, ...Continue Reading

References

Dec 16, 2003·Angewandte Chemie·Wolfgang H BinderFredric M Menger
May 14, 2004·Annual Review of Biophysics and Biomolecular Structure·Kai Simons, Winchil L C Vaz
Dec 29, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Jae-Ho LeeSrinivasa R Raghavan
Dec 29, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Paolo BertoncelloClaudio Nicolini
Feb 24, 2005·Chemical Communications : Chem Comm·Jyongsik Jang, Joonwon Bae
Jun 1, 2005·Chemistry and Physics of Lipids·Siewert J MarrinkAlan E Mark
Sep 13, 2005·Biomacromolecules·Millicent A Firestone, Sönke Seifert
Apr 21, 2006·Nature Reviews. Molecular Cell Biology·John F Hancock
Oct 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Emily E MeyerJacob Israelachvili
Jun 16, 2007·The Journal of Physical Chemistry. B·Siewert J MarrinkAlex H de Vries
Aug 19, 2007·Physical Chemistry Chemical Physics : PCCP·Masaomi Hatakeyama, Roland Faller
Oct 5, 2007·Biochimica Et Biophysica Acta·Morihisa Fujita, Yoshifumi Jigami
Apr 2, 2008·Journal of Colloid and Interface Science·Lin-Chau ChangChurn-Shiouh Gau
Jun 19, 2008·Biochemistry·Margot G Paulick, Carolyn R Bertozzi
Sep 18, 2010·Colloids and Surfaces. B, Biointerfaces·Maksim IonovCostas Demetzos
Sep 22, 2010·Colloids and Surfaces. B, Biointerfaces·Zhi RaoTetsushi Taguchi
Dec 15, 2010·Journal of Molecular Graphics & Modelling·Andrew Hung, Irene Yarovsky
Dec 22, 2010·The Journal of Physical Chemistry. B·Edmund F PalermoKenichi Kuroda
Feb 8, 2011·Biomaterials·Matthew B DowlingSrinivasa R Raghavan
Aug 10, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Jin-Oh YouDebra T Auguste
Oct 14, 2011·Journal of the American Chemical Society·Khizar H Sheikh, Suzanne P Jarvis
May 23, 2012·Colloids and Surfaces. B, Biointerfaces·Zhi Rao, Tetsushi Taguchi
Feb 9, 2013·Journal of the American Chemical Society·Frederick A HeberleJohn Katsaras
Sep 18, 2013·Journal of the American Chemical Society·Frederick A HeberleGerald W Feigenson
Nov 14, 2013·The Journal of Physical Chemistry. B·Susruta SamantaDanilo Roccatano
Oct 16, 2014·Natural Product Reports·J P MartinezA Meyerhans
Jul 25, 2015·Nature Communications·David J BuschJeanne C Stachowiak
Nov 6, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Yan XiaMu-Ping Nieh
Apr 5, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Zachary I ImamJeanne C Stachowiak
Apr 21, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Wade F ZenoMarjorie L Longo
Aug 26, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Yan XiaMu-Ping Nieh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.