Effects of menopause and postmenopausal tibolone treatment on plasma TNFalpha, IL-4, IL-10, IL-12 cytokine pattern and some bone turnover markers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Pervin VuralCemil Akgul

Abstract

To asses plasma TNFalpha, IL-4, IL-10, IL-12; urinary hydroxyproline (Hyp) and calcium as bone resorption markers in healthy postmenopausal women compared with premenopausal ones, and to observe the effect of tibolone (2.5mg/day for 6 months) upon above mentioned parameters. The study involved 24 healthy postmenopausal women (study group) and 25 premenopausal women (control group). Plasma TNFalpha, IL-4, IL-10 and IL-12 concentrations were measured using ELISA kits. Fasting urinary Hyp was measured by Ehrlich's spectrophotometric reaction. Calcium was determined by oxalate precipitation and the redox titration procedure. Statistical significance was analysed by the Mann-Whitney U-test for unpaired data, Wilcoxon Signed Rank test for paired data, and Pearson correlation test. Postmenopausal women (both before and after tibolone treatment) have increased (p<0.001) plasma TNFalpha, IL-4, IL-10, IL-12; and increased urinary Hyp (p<0.05) and calcium (p<0.001) concentrations in comparison with premenopausal individuals. Tibolone treatment has no effect on reversing the increased postmenopausal plasma TNFalpha, IL-4, IL-10 and IL-12, but decreases urinary Hyp and calcium to premenopausal levels. There is a weak positive correlation (r...Continue Reading

Citations

Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Tim J T SutherlandD Robin Taylor
Jul 1, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicoletta BigliaRossella E Nappi
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