Abstract
To asses plasma TNFalpha, IL-4, IL-10, IL-12; urinary hydroxyproline (Hyp) and calcium as bone resorption markers in healthy postmenopausal women compared with premenopausal ones, and to observe the effect of tibolone (2.5mg/day for 6 months) upon above mentioned parameters. The study involved 24 healthy postmenopausal women (study group) and 25 premenopausal women (control group). Plasma TNFalpha, IL-4, IL-10 and IL-12 concentrations were measured using ELISA kits. Fasting urinary Hyp was measured by Ehrlich's spectrophotometric reaction. Calcium was determined by oxalate precipitation and the redox titration procedure. Statistical significance was analysed by the Mann-Whitney U-test for unpaired data, Wilcoxon Signed Rank test for paired data, and Pearson correlation test. Postmenopausal women (both before and after tibolone treatment) have increased (p<0.001) plasma TNFalpha, IL-4, IL-10, IL-12; and increased urinary Hyp (p<0.05) and calcium (p<0.001) concentrations in comparison with premenopausal individuals. Tibolone treatment has no effect on reversing the increased postmenopausal plasma TNFalpha, IL-4, IL-10 and IL-12, but decreases urinary Hyp and calcium to premenopausal levels. There is a weak positive correlation (r...Continue Reading
Citations
Oct 3, 2009·Journal of Bone and Mineral Metabolism·Yin-gang ZhangShijie Wang
Sep 4, 2010·Age·Flora EngelmannIlhem Messaoudi
Dec 20, 2011·Age·Christine MeyerIlhem Messaoudi
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Tim J T SutherlandD Robin Taylor
Jul 1, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicoletta BigliaRossella E Nappi
May 27, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cristina VassalleSilvia Maffei
Aug 3, 2010·Journal of Vascular Surgery·Ageliki G VouyoukaAllan Moscowitz
Feb 10, 2016·PloS One·Flora EngelmannIlhem Messaoudi
Sep 1, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiaomei FengJianguo Xu
Oct 3, 2017·Aging and Disease·Ulises UrzuaMaría-Julieta Gonzalez
Dec 3, 2016·Integrative Cancer Therapies·Danielle LaroucheCaroline Diorio
Nov 7, 2017·Climacteric : the Journal of the International Menopause Society·B CampbellS C Dharmage
Apr 2, 2011·Depression and Anxiety·David R Rubinow, Susan S Girdler
Aug 17, 2016·Menopause : the Journal of the North American Menopause Society·Sahar RazmjouDenis Prud'homme
Jun 8, 2011·Depression and Anxiety·David R Rubinow, Susan S Girdler
Jun 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Andrew J McGovern, George E Barreto
Aug 11, 2021·Scientific Reports·Hetal BhadrichaMeena Desai
Aug 11, 2021·Nutrients·Nikolaos VrachnisZoi Iliodromiti
Jun 26, 2020·ACS Nano·Yuan LiShuilin Wu