Effects of menstrual cycle and oral contraceptive use on serum levels of lipid-soluble antioxidants

American Journal of Obstetrics and Gynecology
Prabhudas R PalanMagdy S Mikhail

Abstract

The purpose of this study was to examine the influence of menstrual cycle and oral contraceptive use on serum levels of lipid-soluble antioxidants. In this cross-section study, nonfasting blood samples were collected twice from 10 healthy premenopausal women during the follicular phase (between days 8 and 11) and the luteal phase (between days 18 and 22) of their same menstrual cycle. In addition, blood samples from 15 premenopausal women who used oral contraceptive for at least 6 months and 40 women who did not use oral contraceptive were collected randomly at any day of the menstrual cycle. Serum levels of coenzyme Q10, alpha-tocopherol, gamma-tocopherol, beta-carotene, alpha-carotene, and lycopene were determined using high pressure liquid chromatography. Serum coenzyme Q10 and alpha-tocopherol levels were significantly lower during the follicular phase compared with the luteal phase of the same menstrual cycle (P < .05). Oral contraceptive use also significantly decreased coenzyme Q10 and alpha-tocopherol (P < .001). Other antioxidant levels were comparable. Alterations in coenzyme Q10 and alpha-tocopherol levels during the menstrual cycle and in oral contraceptive users should be taken into consideration, concerning the fu...Continue Reading

References

Oct 1, 1980·British Journal of Obstetrics and Gynaecology·V Jagadeesan, K Prema
Feb 25, 2003·The Journal of Cardiovascular Nursing·Barbara Sarter
Oct 31, 2003·Molecular Aspects of Medicine·A AzziJ-M Zingg
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Citations

May 13, 2014·Reproductive Biomedicine Online·Simone PaliniCarlo Bulletti
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Daniela GiustariniRanieri Rossi
Feb 14, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Richard W BrowneJean Wactawski-Wende
Dec 21, 2011·Biochimica Et Biophysica Acta·Lucia CiccoliJoussef Hayek
Sep 18, 2008·Redox Report : Communications in Free Radical Research·Agata Karowicz-BilinskaGrzegorz Bartosz
Nov 20, 2015·The Journal of Nutrition·Sunni L MumfordEnrique F Schisterman
Jul 6, 2014·BMC Research Notes·Simone OnurFrank Döring

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